In vivo angiogenesis by platelet-derived wound-healing formula in injured spinal cord.

In vivo angiogenesis was investigated using platelet-derived wound-healing formula (PDWHF) in the injured cat spinal cord. Twenty-two gauge teflon sheaths, which had been coated with PDWHF-Hydron or only with Hydron, were inserted into the spinal cords of cats and the injured cats were maintained for 3 weeks. Selection of PDWHF-Hydron or Hydron was double blinded. The PDWHF-Hydron group showed notable neovascularization as well as dilation around the injury site, and this was statistically significant when compared to the control group. PDWHF seems to play a role in the healing processes of spinal cord injury and may have important interactions with other growth factors and in particular neurogenic growth factor.