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Literature DB >> 7680492

The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis.

T Miyata¹, J Takeda, Y Iida, N Yamada, N Inoue, M Takahashi, K Maeda, T Kitani, T Kinoshita.

Abstract

The glycosylphosphatidylinositol (GPI) anchor is a membrane attachment structure of many proteins and occurs in a wide variety of eukaryotes from yeasts to mammals. The structure of the core of the GPI anchor is conserved in protozoa and mammals and so is its biosynthetic pathway. A complementary DNA encoding a human protein termed PIG-A (phosphatidylinositol glycan-class A) was cloned. PIG-A was necessary for synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.

Entities: Chemical Gene Species

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Year: 1993 PMID： 7680492 DOI： 10.1126/science.7680492

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

128 in total

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