Literature DB >> 7680296

Spontaneous in vitro production of rheumatoid factor during infectious exacerbations of cystic fibrosis: correlation with circulating immune complex levels.

M T Keogan1, M Callaghan, G Yanni, D Mulherin, C Feighery, D L Brown, M X Fitzgerald, B Bresnihan.   

Abstract

Rheumatoid factor (RF) production has been demonstrated during infections, including infectious exacerbations of cystic fibrosis (CF). The aim of this study was to evaluate the relationship of RF production to infection, and examine the mechanisms involved. Serial peripheral blood mononuclear cell (PBMC) cultures with measurement of spontaneous production of IgM RF, IgA RF, total IgM and IgA, and measurement of serum levels of immune complexes were carried out during exacerbations of CF. The percentage of B cells expressing CD5 was examined in a second cohort of acutely infected CF patients, and related to IgM RF production. IgM RF production was significantly elevated during acute infection compared with convalescence (P < 0.05), stable CF subjects (P < 0.005) and normal controls (P < 0.05). IgM RF production did not correlate with total IgM production in the majority of patients, but was closely related to circulating immune complex levels in 8/10 subjects. IgA RF production did not increase significantly during infection, and did not correlate with total IgA or IgM RF production, or with circulating immune complex levels. CD5+ B cells were not increased in the CF group, and the percentage of CD5+ B cells did not correlate with IgM RF synthesis. These observations suggest that RF production during infection is specifically induced, possibly by immune complex autoimmunization, and is not simply the result of polyclonal B cell activation. Different patterns of IgM RF and IgA RF synthesis suggest different mechanisms of induction.

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Year:  1993        PMID: 7680296      PMCID: PMC1554730          DOI: 10.1111/j.1365-2249.1993.tb05925.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN: 0009-9104            Impact factor:   4.330


  27 in total

1.  Transient appearance of the rheumatoid factor in connection with prophylactic vaccinations.

Authors:  K AHO; A KONTTINEN; M RAJASALMI; O WAGER
Journal:  Acta Pathol Microbiol Scand       Date:  1962

2.  Immunochemical quantitation of antigens by single radial immunodiffusion.

Authors:  G Mancini; A O Carbonara; J F Heremans
Journal:  Immunochemistry       Date:  1965-09

3.  Increased frequency of rheumatoid factor precursor B lymphocytes after immunization of normal adults with tetanus toxoid.

Authors:  M J Welch; S Fong; J Vaughan; D Carson
Journal:  Clin Exp Immunol       Date:  1983-02       Impact factor: 4.330

4.  Routine assay for detection of IgG and IgM antiglobulins in seronegative and seropositive rheumatoid arthritis.

Authors:  F C Hay; L J Nineham; I M Roitt
Journal:  Br Med J       Date:  1975-07-26

5.  Longitudinal study of circulating immune complexes in a patient with Staphylococcus albus-induced shunt nephritis.

Authors:  G D Harkiss; D L Brown; D B Evans
Journal:  Clin Exp Immunol       Date:  1979-08       Impact factor: 4.330

6.  IgM rheumatoid factors in mice injected with bacterial lipopolysaccharides.

Authors:  S Izui; R A Eisenberg; F J Dixon
Journal:  J Immunol       Date:  1979-05       Impact factor: 5.422

7.  IgA rheumatoid factor in the sera and saliva of patients with rheumatoid arthritis and Sjögren's syndrome.

Authors:  J V Dunne; D A Carson; H L Spiegelberg; M A Alspaugh; J H Vaughan
Journal:  Ann Rheum Dis       Date:  1979-04       Impact factor: 19.103

8.  Rheumatoid factors and secondary immune responses in the mouse. I. Frequent occurrence of hybridomas secreting IgM anti-IgG1 autoantibodies after immunization with protein antigens.

Authors:  J Van Snick; P Coulie
Journal:  Eur J Immunol       Date:  1983-11       Impact factor: 5.532

9.  Rheumatoid factor-like immunoglobulin M protects previously uninfected rat pups and dams from Trypanosoma lewisi.

Authors:  A B Clarkson; G H Mellow
Journal:  Science       Date:  1981-10-09       Impact factor: 47.728

10.  IgG rheumatoid factor in subacute bacterial endocarditis: relationship to IgM rheumatoid factor and circulating immune complexes.

Authors:  D A Carson; A S Bayer; R A Eisenberg; S Lawrance; A Theofilopoulos
Journal:  Clin Exp Immunol       Date:  1978-01       Impact factor: 4.330

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  3 in total

Review 1.  Joint disorders in cystic fibrosis.

Authors:  M A Turner; E Baildam; L Patel; T J David
Journal:  J R Soc Med       Date:  1997       Impact factor: 5.344

2.  Persistence of a rheumatoid factor (RF)-producing B cell clone with a somatically mutated Ig kappa chain in a patient with rheumatoid arthritis.

Authors:  A Schrauder; A Gause; W Jung; R Mierau; M Pfreundschuh
Journal:  Clin Exp Immunol       Date:  1994-08       Impact factor: 4.330

3.  IL-2 enhances polyclonal IgM but not IgM-rheumatoid factor synthesis by activated human peripheral blood B cells.

Authors:  M Callaghan; A Whelan; C Feighery; B Bresnihan
Journal:  Clin Exp Immunol       Date:  1993-08       Impact factor: 4.330

  3 in total

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