Literature DB >> 7679901

Tyrosine phosphorylation of phospholipase C gamma in c-met/HGF receptor-stimulated hepatocytes: comparison with HepG2 hepatocarcinoma cells.

Y Okano1, K Mizuno, S Osada, T Nakamura, Y Nozawa.   

Abstract

Hepatocyte growth factor (HGF) stimulates inositol 1,4,5-trisphosphate (InsP3) formation in rat primary cultured hepatocytes, which is inhibited by the pretreatment with a tyrosine kinase inhibitor, genistein. This InsP3 production was coincident with tyrosine phosphorylation of phospholipase C gamma (PLC gamma), detected in immunoprecipitates with anti-PLC gamma, suggesting activation mechanism of PLC gamma by tyrosine phosphorylation. However, in human hepatocarcinoma HepG2 cells, HGF, which suppresses cell growth, causes neither phosphorylation of PLC gamma nor InsP3 formation. The results suggests that PLC gamma in normal hepatocytes was activated by HGF through tyrosine kinase of HGF receptor.

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Year:  1993        PMID： 7679901     DOI： 10.1006/bbrc.1993.1125

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  13 in total

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2.  Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain.

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Journal:  Int J Exp Pathol       Date:  2000-02       Impact factor: 1.925

4.  Ganglioside GM3 promotes HGF-stimulated motility of murine hepatoma cell through enhanced phosphorylation of cMet at specific tyrosine sites and PI3K/Akt-mediated migration signaling.

Authors:  Ying Li; Xiaohua Huang; Weiliang Zhong; Jianing Zhang; Keli Ma
Journal:  Mol Cell Biochem       Date:  2013-06-08       Impact factor: 3.396

5.  Transduction of basolateral-to-apical signals across epithelial cells: ligand-stimulated transcytosis of the polymeric immunoglobulin receptor requires two signals.

Authors:  F Luton; K E Mostov
Journal:  Mol Biol Cell       Date:  1999-05       Impact factor: 4.138

6.  VEGF stimulates RCAN1.4 expression in endothelial cells via a pathway requiring Ca2+/calcineurin and protein kinase C-delta.

Authors:  Katherine Holmes; Elinor Chapman; Violaine See; Michael J Cross
Journal:  PLoS One       Date:  2010-07-06       Impact factor: 3.240

7.  c-Met must translocate to the nucleus to initiate calcium signals.

Authors:  Dawidson A Gomes; Michele A Rodrigues; M Fatima Leite; Marcus V Gomez; Peter Varnai; Tamas Balla; Anton M Bennett; Michael H Nathanson
Journal:  J Biol Chem       Date:  2007-12-11       Impact factor: 5.157

8.  Biochemical and pharmacological characterization of human c-Met neutralizing monoclonal antibody CE-355621.

Authors:  Neil R Michaud; Jitesh P Jani; Stephen Hillerman; Konstantinos E Tsaparikos; Elsa G Barbacci-Tobin; Elisabeth Knauth; Henry Putz; Mary Campbell; George A Karam; Boris Chrunyk; David F Gebhard; Larry L Green; Jinghai J Xu; Margaret C Dunn; Tim M Coskran; Jean-Martin Lapointe; Bruce D Cohen; Kevin G Coleman; Vahe Bedian; Patrick Vincent; Shama Kajiji; Stefan J Steyn; Gary V Borzillo; Gerrit Los
Journal:  MAbs       Date:  2012-09-24       Impact factor: 5.857

9.  Hepatocyte growth factor activates endothelial nitric oxide synthase by Ca(2+)- and phosphoinositide 3-kinase/Akt-dependent phosphorylation in aortic endothelial cells.

Authors:  Kennedy Makondo; Kazuhiro Kimura; Naoki Kitamura; Takanori Kitamura; Daisuke Yamaji; Bae Dong Jung; Masayuki Saito
Journal:  Biochem J       Date:  2003-08-15       Impact factor: 3.857

10.  Characterization of the enhancing effect of protamine on the proliferative activity of hepatocyte growth factor in rat hepatocytes.

Authors:  Ke-Xin Liu; Yukio Kato; Kunio Matsumoto; Toshikazu Nakamura; Taiichi Kaku; Yuichi Sugiyama
Journal:  Pharm Res       Date:  2009-01-06       Impact factor: 4.200
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