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Literature DB >> 7679793

Aluminofluoride activates hyperpolarization- and stretch-activated cationic channels in single smooth muscle cells.

Abstract

Aluminofluoride (AF) has a variety of biological actions such as activation of GTP binding proteins and inhibition of phosphatases. In the present study, the effects of AF on hyper-polarization- and stretch-activated cationic channels (HA-SACs) were investigated in isolated gastric smooth muscle cells from the toad, Bufo marinus, using the patch-clamp technique. In cell-attached patches extracellular application of AF (20 mM KF plus 20 microM AlCl3) reversibly increased HA-SAC activity without changing its voltage sensitivity. The single channel current amplitude of HA-SACs was not affected during this procedure. The mechanism of AF-induced activation of HA-SACs remains unclear. However, this activation may play a role in contraction of smooth muscle induced by AF.

Entities: Chemical Species

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Year: 1993 PMID： 7679793 DOI： 10.1007/bf00374297

Source DB: PubMed Journal: Pflugers Arch ISSN： 0031-6768 Impact factor: 3.657

17 in total

1. AlF4- induces Ca2+ oscillations in guinea-pig ileal smooth muscle.

Authors: B Himpens; L Missiaen; G Droogmans; R Casteels
Journal: Pflugers Arch Date: 1991-02 Impact factor: 3.657

2. Effects of acetylcholine and substance P on electrical activity of intact toad gastric muscles.

Authors: P Y Shonnard; K M Sanders
Journal: Am J Physiol Date: 1990-01

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Authors: P Ackrill; J P Day
Journal: Contrib Nephrol Date: 1984 Impact factor: 1.580

4. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

Authors: O P Hamill; A Marty; E Neher; B Sakmann; F J Sigworth
Journal: Pflugers Arch Date: 1981-08 Impact factor: 3.657

5. Guanine nucleotide binding proteins may modulate gating of calcium channels in vascular smooth muscle. I. Studies with fluoride.

Authors: Y Y Zeng; C G Benishin; P K Pang
Journal: J Pharmacol Exp Ther Date: 1989-07 Impact factor: 4.030

6. Modulation of fluoroaluminate-induced inositol phosphate formation by increases in tissue cyclic AMP content in bovine tracheal smooth muscle.

Authors: I P Hall; J Donaldson; S J Hill
Journal: Br J Pharmacol Date: 1990-07 Impact factor: 8.739

Review 7. The chemistry of aluminum as related to biology and medicine.

Authors: R B Martin
Journal: Clin Chem Date: 1986-10 Impact factor: 8.327

8. Fluoroaluminates mimic muscarinic- and oxytocin-receptor-mediated generation of inositol phosphates and contraction in the intact guinea-pig myometrium. Role for a pertussis/cholera-toxin-insensitive G protein.

Authors: S Marc; D Leiber; S Harbon
Journal: Biochem J Date: 1988-10-15 Impact factor: 3.857

Aluminofluoride activates hyperpolarization- and stretch-activated cationic channels in single smooth muscle cells.

1. AlF4- induces Ca2+ oscillations in guinea-pig ileal smooth muscle.

2. Effects of acetylcholine and substance P on electrical activity of intact toad gastric muscles.

3. Therapy of aluminium overload (II).

4. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

5. Guanine nucleotide binding proteins may modulate gating of calcium channels in vascular smooth muscle. I. Studies with fluoride.

6. Modulation of fluoroaluminate-induced inositol phosphate formation by increases in tissue cyclic AMP content in bovine tracheal smooth muscle.

Review 7. The chemistry of aluminum as related to biology and medicine.

8. Fluoroaluminates mimic muscarinic- and oxytocin-receptor-mediated generation of inositol phosphates and contraction in the intact guinea-pig myometrium. Role for a pertussis/cholera-toxin-insensitive G protein.

9. Differential activation of rabbit femoral arteries by aluminum fluoride and sodium fluoride.

10. Regulation of cardiac pacemaker current If in excised membranes from sinoatrial node cells.

1. The mechanism of acidic pH-induced contraction in aortae from SHR and WKY rats enhanced by increasing blood pressure.

Review 2. Mechanosensitive Piezo Channels in the Gastrointestinal Tract.