Literature DB >> 7679525

Severe bleomycin lung toxicity: reversal with high dose corticosteroids.

J Maher1, P A Daly.   

Abstract

A 42 year old man, treated for testicular carcinoma with combination chemotherapy that included bleomycin, developed life threatening interstitial pneumonitis. He recovered successfully after treatment with very high doses of corticosteroids and azathioprine. This report suggests that bleomycin lung toxicity may be reversible if treated aggressively.

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Year:  1993        PMID： 7679525      PMCID： PMC464261          DOI： 10.1136/thx.48.1.92

Source DB:  PubMed          Journal:  Thorax        ISSN： 0040-6376            Impact factor:   9.139


  8 in total

1.  Reactivation of bleomycin lung toxicity following oxygen administration. A second response to corticosteroids.

Authors:  A J Gilson; S A Sahn
Journal:  Chest       Date:  1985-08       Impact factor: 9.410

2.  New antibiotics, bleomycin A and B.

Authors:  H Umezawa; K Maeda; T Takeuchi; Y Okami
Journal:  J Antibiot (Tokyo)       Date:  1966-09       Impact factor: 2.649

Review 3.  Bleomycin-induced pulmonary toxicity.

Authors:  K Jules-Elysee; D A White
Journal:  Clin Chest Med       Date:  1990-03       Impact factor: 2.878

Review 4.  Possible mechanisms of bleomycin-induced fibrosis.

Authors:  D B Chandler
Journal:  Clin Chest Med       Date:  1990-03       Impact factor: 2.878

5.  Life-threatening bleomycin pulmonary toxicity with ultimate reversibility.

Authors:  L C Hartmann; S Frytak; R L Richardson; D T Coles; R E Cupps
Journal:  Chest       Date:  1990-08       Impact factor: 9.410

6.  Large-dose bleomycin therapy and pulmonary toxicity. A possible role of prior radiotherapy.

Authors:  M L Samuels; D E Johnson; P Y Holoye; V J Lanzotti
Journal:  JAMA       Date:  1976-03-15       Impact factor: 56.272

7.  Inhibition of collagen accumulation by glucocorticoids in rat lung after intratracheal bleomycin instillation.

Authors:  K M Sterling; T DiPetrillo; K R Cutroneo; A Prestayko
Journal:  Cancer Res       Date:  1982-02       Impact factor: 12.701

8.  Bleomycin hypersensitivity pneumonitis.

Authors:  P Y Holoye; M A Luna; B MacKay; C W Bedrossian
Journal:  Ann Intern Med       Date:  1978-01       Impact factor: 25.391
  8 in total
  6 in total

1.  Bleomycin lung: a case report.

Authors:  Rabia Sofia Rashid
Journal:  BMJ Case Rep       Date:  2009-04-14

Review 2.  Complications associated with chemotherapy in testicular cancer management.

Authors:  Chunkit Fung; David J Vaughn
Journal:  Nat Rev Urol       Date:  2011-03-15       Impact factor: 14.432

Review 3.  Long-term complications of chemotherapy for germ cell tumours.

Authors:  Uzair B Chaudhary; Jason R Haldas
Journal:  Drugs       Date:  2003       Impact factor: 9.546

Review 4.  Diagnosis and management of drug-associated interstitial lung disease.

Authors:  N L Müller; D A White; H Jiang; A Gemma
Journal:  Br J Cancer       Date:  2004-08       Impact factor: 7.640

5.  Imatinib for bleomycin induced pulmonary toxicity: a case report and evidence-base review.

Authors:  Iouri Banakh; Alice Lam; Ravindranath Tiruvoipati; Ian Carney; John Botha
Journal:  Clin Case Rep       Date:  2016-04-01

Review 6.  Development of a best-practice clinical guideline for the use of bleomycin in the treatment of germ cell tumours in the UK.

Authors:  Robert A Watson; Hugo De La Peña; Maria T Tsakok; Johnson Joseph; Sara Stoneham; Jonathan Shamash; Johnathan Joffe; Danish Mazhar; Zoe Traill; Ling-Pei Ho; Sue Brand; Andrew S Protheroe
Journal:  Br J Cancer       Date:  2018-10-25       Impact factor: 7.640
  6 in total

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