Literature DB >> 7678422

A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen.

M S Diamond1, T A Springer.   

Abstract

We report that a subpopulation (10%) of the Mac-1 (CD1 1b/CD18) molecules on activated neutrophils mediates adhesion to ICAM-1 and fibrinogen. We describe a novel mAb (CBRM1/5) that binds to an activation-specific neoepitope on a subset of Mac-1 molecules on neutrophils and monocytes after stimulation with chemoattractants or phorobol esters but does not recognize Mac-1 on resting myeloid cells. CBRM1/5 immunoprecipitates a subpopulation of Mac-1 molecules from detergent lysates of neutrophils, binds to immunoaffinity-purified Mac-1, and localizes to the I domain on the alpha chain of Mac-1. Because CBRM1/5 recognizes a fraction of Mac-1 on activated neutrophils, but still blocks Mac-1-dependent adhesion to fibrinogen and ICAM-1, we suggest that only a small subset of Mac-1 molecules is competent to mediate adhesion.

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Year:  1993        PMID： 7678422      PMCID： PMC2119505          DOI： 10.1083/jcb.120.2.545

Source DB:  PubMed          Journal:  J Cell Biol        ISSN： 0021-9525            Impact factor:   10.539


  79 in total

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Journal:  Cell Regul       Date:  1990-11

2.  Enhanced autoradiographic detection of 32P and 125I using intensifying screens and hypersensitized film.

Authors:  R A Laskey; A D Mills
Journal:  FEBS Lett       Date:  1977-10-15       Impact factor: 4.124

3.  Single-step separation of red blood cells. Granulocytes and mononuclear leukocytes on discontinuous density gradients of Ficoll-Hypaque.

Authors:  D English; B R Andersen
Journal:  J Immunol Methods       Date:  1974-08       Impact factor: 2.303

4.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

5.  Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation.

Authors:  M S Diamond; D E Staunton; S D Marlin; T A Springer
Journal:  Cell       Date:  1991-06-14       Impact factor: 41.582

6.  Ligands "activate" integrin alpha IIb beta 3 (platelet GPIIb-IIIa).

Authors:  X P Du; E F Plow; A L Frelinger; T E O'Toole; J C Loftus; M H Ginsberg
Journal:  Cell       Date:  1991-05-03       Impact factor: 41.582

7.  The leukocyte integrin LFA-1 reconstituted by cDNA transfection in a nonhematopoietic cell line is functionally active and not transiently regulated.

Authors:  R S Larson; M L Hibbs; T A Springer
Journal:  Cell Regul       Date:  1990-03

8.  Lectin-like cell adhesion molecule 1 mediates leukocyte rolling in mesenteric venules in vivo.

Authors:  K Ley; P Gaehtgens; C Fennie; M S Singer; L A Lasky; S D Rosen
Journal:  Blood       Date:  1991-06-15       Impact factor: 22.113

9.  Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins.

Authors:  M B Lawrence; T A Springer
Journal:  Cell       Date:  1991-05-31       Impact factor: 41.582

10.  Quantitative investigations of the adhesiveness of circulating polymorphonuclear leucocytes to blood vessel walls.

Authors:  A Atherton; G V Born
Journal:  J Physiol       Date:  1972-04       Impact factor: 5.182
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  118 in total

1.  Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds.

Authors:  Motomu Shimaoka; Chafen Lu; Azucena Salas; Tsan Xiao; Junichi Takagi; Timothy A Springer
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-04       Impact factor: 11.205

2.  Role of c-Abl in L-selectin shedding from the neutrophil surface.

Authors:  Carissa J Ball; Michael R King
Journal:  Blood Cells Mol Dis       Date:  2011-02-01       Impact factor: 3.039

3.  Micromechanical tests of adhesion dynamics between neutrophils and immobilized ICAM-1.

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Journal:  Biophys J       Date:  2004-02       Impact factor: 4.033

4.  Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.

Authors:  Motomu Shimaoka; Tsan Xiao; Jin-Huan Liu; Yuting Yang; Yicheng Dong; Chang-Duk Jun; Alison McCormack; Rongguang Zhang; Andrzej Joachimiak; Junichi Takagi; Jia-Huai Wang; Timothy A Springer
Journal:  Cell       Date:  2003-01-10       Impact factor: 41.582

5.  Neutrophil adhesive contact dependence on impingement force.

Authors:  C M Spillmann; E Lomakina; R E Waugh
Journal:  Biophys J       Date:  2004-09-10       Impact factor: 4.033

Review 6.  Leukocyte integrin activation and deactivation: novel mechanisms of balancing inflammation.

Authors:  Alexander Zarbock; Tibor Kempf; Kai C Wollert; Dietmar Vestweber
Journal:  J Mol Med (Berl)       Date:  2011-11-19       Impact factor: 4.599

7.  Conformational changes in tertiary structure near the ligand binding site of an integrin I domain.

Authors:  C Oxvig; C Lu; T A Springer
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-02       Impact factor: 11.205

8.  Soluble beta-glucan polysaccharide binding to the lectin site of neutrophil or natural killer cell complement receptor type 3 (CD11b/CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3b-opsonized target cells.

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Journal:  J Clin Invest       Date:  1996-07-01       Impact factor: 14.808

Review 9.  Adhesion molecules and transplantation.

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Journal:  Ann Surg       Date:  1994-01       Impact factor: 12.969

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Journal:  J Cyst Fibros       Date:  2015-03-11       Impact factor: 5.482
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