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Literature DB >> 7677754

Mutant IGF-I receptors as dominant negatives for growth and transformation.

Abstract

The insulin-like growth factor I receptor (IGF-IR) plays a crucial role in cell growth, transformation and protection from apoptosis. We have transfected several mutant IGF-IRs into C6 rat glioblastoma cells, in order to determine whether they can act as dominant negatives. We find that some of them can act as dominant negatives in growth assays (monolayer or soft agar), but that none of those examined can induce apoptosis in C6 cells.

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Year: 1995 PMID： 7677754 DOI： 10.1006/bbrc.1995.2311

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

13 in total

1. IGF-1 Receptor Modulates FoxO1-Mediated Tamoxifen Response in Breast Cancer Cells.

Authors: Ali Vaziri-Gohar; Yan Zheng; Kevin D Houston
Journal: Mol Cancer Res Date: 2017-01-17 Impact factor: 5.852

2. Insulin-like growth factor I receptor signaling in transformation by src oncogenes.

Authors: B Valentinis; A Morrione; S J Taylor; R Baserga
Journal: Mol Cell Biol Date: 1997-07 Impact factor: 4.272

Review 3. The IGF/IGFBP system in CNS malignancy.

Authors: W Zumkeller; M Westphal
Journal: Mol Pathol Date: 2001-08

4. Insulin-like growth factor I synergizes with interleukin 4 for hematopoietic cell proliferation independent of insulin receptor substrate expression.

Authors: L Soon; L Flechner; J S Gutkind; L H Wang; R Baserga; J H Pierce; W Li
Journal: Mol Cell Biol Date: 1999-05 Impact factor: 4.272

5. Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts.

Authors: Y Min; Y Adachi; H Yamamoto; A Imsumran; Y Arimura; T Endo; Y Hinoda; C-T Lee; S Nadaf; D P Carbone; K Imai
Journal: Gut Date: 2005-05 Impact factor: 23.059

6. Insulin-like growth factor-1 inscribes a gene expression profile for angiogenic factors and cancer progression in breast epithelial cells.

Authors: J S Oh; J E Kucab; P R Bushel; K Martin; L Bennett; J Collins; R P DiAugustine; J C Barrett; C A Afshari; S E Dunn
Journal: Neoplasia Date: 2002 May-Jun Impact factor: 5.715

Mutant IGF-I receptors as dominant negatives for growth and transformation.

1. IGF-1 Receptor Modulates FoxO1-Mediated Tamoxifen Response in Breast Cancer Cells.

2. Insulin-like growth factor I receptor signaling in transformation by src oncogenes.

Review 3. The IGF/IGFBP system in CNS malignancy.

4. Insulin-like growth factor I synergizes with interleukin 4 for hematopoietic cell proliferation independent of insulin receptor substrate expression.

5. Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts.

6. Insulin-like growth factor-1 inscribes a gene expression profile for angiogenic factors and cancer progression in breast epithelial cells.

7. GPER1-mediated IGFBP-1 induction modulates IGF-1-dependent signaling in tamoxifen-treated breast cancer cells.

8. Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis.

9. Human malignant glioma therapy using anti-alpha(v)beta3 integrin agents.

10. The IGF pathway regulates ERα through a S6K1-dependent mechanism in breast cancer cells.