OBJECTIVE: To evaluate the effectiveness of an oxidized regenerated cellulose absorbable barrier (Interceed [TC7] Absorbable Adhesion Barrier) in the reduction of adhesion reformationafter laparoscopic surgery for endometriosis. METHODS:Thirty-two premenopausal nonpregnant women who had severe endometriosis and complete posterior cul-de-sac obliteration and were undergoing laparoscopic surgery were randomly assigned to either surgery alone or surgery and Interceed. None of the subjects received any other treatment for adhesion prevention. Second-look laparoscopy was performed 12-14 weeks after laparoscopic surgery by an investigator blinded to the treatment, and the incidence of adhesion-free subjects was assessed. RESULTS: Twelve of 16 (75%) women treated with the oxidized regenerated cellulose barrier were free of adhesions, compared with two of 16 (12.5%) controls, a statistically significant difference (P < .05). CONCLUSION: The oxidized regenerated cellulose absorbable barrier significantly reduces adhesion reformationafter laparoscopic surgery for endometriosis.
RCT Entities:
OBJECTIVE: To evaluate the effectiveness of an oxidized regenerated cellulose absorbable barrier (Interceed [TC7] Absorbable Adhesion Barrier) in the reduction of adhesion reformation after laparoscopic surgery for endometriosis. METHODS: Thirty-two premenopausal nonpregnant women who had severe endometriosis and complete posterior cul-de-sac obliteration and were undergoing laparoscopic surgery were randomly assigned to either surgery alone or surgery and Interceed. None of the subjects received any other treatment for adhesion prevention. Second-look laparoscopy was performed 12-14 weeks after laparoscopic surgery by an investigator blinded to the treatment, and the incidence of adhesion-free subjects was assessed. RESULTS: Twelve of 16 (75%) women treated with the oxidized regenerated cellulose barrier were free of adhesions, compared with two of 16 (12.5%) controls, a statistically significant difference (P < .05). CONCLUSION: The oxidized regenerated cellulose absorbable barrier significantly reduces adhesion reformation after laparoscopic surgery for endometriosis.
Authors: Rosi P Balbinotto; Ana L Muller; André G Nunes; Rodrigo Da Silva; Fabíola S Meyer; Carlos S Cerski; Manoel M Trindade Journal: Surg Endosc Date: 2011-03-17 Impact factor: 4.584
Authors: Bernhard Krämer; Jürgen Andress; Felix Neis; Sascha Hoffmann; Sara Brucker; Stefan Kommoss; Alice Höller Journal: Langenbecks Arch Surg Date: 2021-05-26 Impact factor: 3.445