Literature DB >> 7674810

Insulin-like growth factor I (IGF-I) affects plasma lipid profile and inhibits the lipolytic action of growth hormone (GH) in isolated adipocytes.

M Pascual1, J Larralde, J A Martínez.   

Abstract

The actions of insulin-like growth factor I (IGF-I) and growth hormone (GH) on lipid metabolism have been investigated in hormonally intact rats. The subcutaneous injection of IGF-I (100 micrograms) and GH (100 micrograms) lowered total cholesterol plasma levels. The in vitro assays on isolated rat adipocytes showed an antilipolytic effect of IGF-I on GH induced lipolysis. All these data support an important role for IGF-I and GH on the regulation of lipid metabolism.

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Year:  1995        PMID： 7674810     DOI： 10.1016/0024-3205(95)02067-s

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  5 in total

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Authors:  J A Martínez; M Aguado; G Frühbeck
Journal:  J Physiol Biochem       Date:  2000-03       Impact factor: 4.158

2.  Effects of GH-IGF-I excess and gonadal status on bone mineral density and body composition in patients with acromegaly.

Authors:  M Madeira; L V Neto; G A B de Lima; R O Moreira; L M C de Mendonça; M R Gadelha; M L F Farias
Journal:  Osteoporos Int       Date:  2010-03-20       Impact factor: 4.507

3.  Effects of earthworm extract on the lipid profile and fatty liver induced by a high-fat diet in guinea pigs.

Authors:  Zhenhan Deng; Shanshan Gao; Yunfei An; Yong Huang; Haifeng Liu; Weimin Zhu; Wei Lu; Miao He; Wenqing Xie; Dengjie Yu; Yusheng Li
Journal:  Ann Transl Med       Date:  2021-02

4.  Unexpected role for IGF-1 in starvation: Maintenance of blood glucose.

Authors:  Fei Fang; Joseph L Goldstein; Xuanming Shi; Guosheng Liang; Michael S Brown
Journal:  Proc Natl Acad Sci U S A       Date:  2022-08-01       Impact factor: 12.779

5.  Obestatin and growth hormone reveal the interaction of central obesity and other cardiometabolic risk factors of metabolic syndrome.

Authors:  Angus P Yu; Felix N Ugwu; Bjorn T Tam; Paul H Lee; Vicki Ma; Simon Pang; Angel S Chow; Kenneth K Cheng; Christopher W Lai; Cesar S Wong; Parco M Siu
Journal:  Sci Rep       Date:  2020-03-26       Impact factor: 4.379
  5 in total

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