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Literature DB >> 7673950

Treatment of multifocal motor neuropathy with high dose intravenous immunoglobulins: a double blind, placebo controlled study.

L H Van den Berg¹, H Kerkhoff, P L Oey, H Franssen, I Mollee, M Vermeulen, F G Jennekens, J H Wokke.

Abstract

The effect of high dose intravenous immunoglobulin (IVIg) treatment was studied in six patients with multifocal motor neuropathy (MMN). All patients responded to treatment (0.4 g/kg for five consecutive days) in an open trial. The effect of IVIg treatment was confirmed for each patient in a single patient, double blind, placebo controlled trial. Four patients received two IVIg treatments and two placebo treatments, and two patients received one IVIg and one placebo treatment in a randomised order. Five out of six patients responded to IVIg but not to placebo. One patient responded to IVIg in the same manner as to placebo treatment. Thus IVIg treatment can lead to improvement of muscle strength in patients with MMN.

Entities: Disease Species

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Year: 1995 PMID： 7673950 PMCID： PMC486021 DOI： 10.1136/jnnp.59.3.248

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

13 in total

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2. Intravenous immunoglobulin treatment in patients with chronic inflammatory demyelinating polyneuropathy. Clinical and laboratory characteristics associated with improvement.

Authors: P A van Doorn; M Vermeulen; A Brand; P G Mulder; H F Busch
Journal: Arch Neurol Date: 1991-02

3. Intravenous immunoglobulin treatment in patients with motor neuron syndromes associated with anti-GM1 antibodies: a double-blind, placebo-controlled study.

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4. Amyotrophic lateral sclerosis: theories and therapies.

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Review 5. Antiglycolipid antibodies in peripheral neuropathy: fact or fiction?

Authors: H J Willison
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6. A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside.

Authors: A Pestronk; D R Cornblath; A A Ilyas; H Baba; R H Quarles; J W Griffin; K Alderson; R N Adams
Journal: Ann Neurol Date: 1988-07 Impact factor: 10.422

7. Multifocal motor neuropathy: response to human immune globulin.

Authors: V Chaudhry; A M Corse; D R Cornblath; R W Kuncl; D B Drachman; M L Freimer; R G Miller; J W Griffin
Journal: Ann Neurol Date: 1993-03 Impact factor: 10.422

8. High-dose intravenous immunoglobulin therapy in multifocal motor neuropathy.

Authors: E Nobile-Orazio; N Meucci; S Barbieri; M Carpo; G Scarlato
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9. Single-patient randomised clinical trial. Use in determining optimum treatment for patient with inflammation of Kock continent ileostomy reservoir.

Authors: R S McLeod; D W Taylor; Z Cohen; J B Cullen
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10. Multifocal motor neuropathy with conduction block: is it a distinct clinical entity?

Authors: D J Lange; W Trojaborg; N Latov; A P Hays; D S Younger; A Uncini; D M Blake; M Hirano; S M Burns; R E Lovelace
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46 in total

Review 1. Treatment of chronic inflammatory demyelinating polyneuropathy.

Authors: G Comi; L Roveri
Journal: Ital J Neurol Sci Date: 1998-10

Review 2. Can polyclonal intravenous immunoglobulin limit cytokine mediated cerebral damage and chronic lung disease in preterm infants?

Authors: P V Mohan; W Tarnow-Mordi; B Stenson; P Brocklehurst; K Haque; V Cavendish; A Cust
Journal: Arch Dis Child Fetal Neonatal Ed Date: 2004-01 Impact factor: 5.747

Treatment of multifocal motor neuropathy with high dose intravenous immunoglobulins: a double blind, placebo controlled study.

1. Hand-held myometry: reference values.

2. Intravenous immunoglobulin treatment in patients with chronic inflammatory demyelinating polyneuropathy. Clinical and laboratory characteristics associated with improvement.

3. Intravenous immunoglobulin treatment in patients with motor neuron syndromes associated with anti-GM1 antibodies: a double-blind, placebo-controlled study.

4. Amyotrophic lateral sclerosis: theories and therapies.

Review 5. Antiglycolipid antibodies in peripheral neuropathy: fact or fiction?

6. A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside.

7. Multifocal motor neuropathy: response to human immune globulin.

8. High-dose intravenous immunoglobulin therapy in multifocal motor neuropathy.

9. Single-patient randomised clinical trial. Use in determining optimum treatment for patient with inflammation of Kock continent ileostomy reservoir.

10. Multifocal motor neuropathy with conduction block: is it a distinct clinical entity?

Review 1. Treatment of chronic inflammatory demyelinating polyneuropathy.

Review 2. Can polyclonal intravenous immunoglobulin limit cytokine mediated cerebral damage and chronic lung disease in preterm infants?

Review 3. Management of chronic inflammatory demyelinating polyradiculoneuropathy.

Review 4. [Use of i.v. immunoglobulins in neurology. Evidence-based consensus].

Review 5. Multifocal motor neuropathy: diagnosis, pathogenesis and treatment strategies.

6. New advances in the treatment of neurological diseases using high dose intravenous immunoglobulins.

Review 7. Intravenous immunoglobulin in therapy of peripheral neuropathy.

8. The effect of treatment upon temporal dispersion in IvIg responsive multifocal motor neuropathy.

9. A practical definition of conduction block in IvIg responsive multifocal motor neuropathy.

Review 10. Therapy of immune neuropathies with intravenous immunoglobulins.