Literature DB >> 7673943

Aplysillin A, a thrombin receptor antagonist from the marine sponge Aplysina fistularis fulva.

N K Gulavita1, S A Pomponi, A E Wright, M Garay, M A Sills.   

Abstract

Aplysillin A [1], an unusual disulfate ester of a 1,4-diphenyl-1,3-butadiene, was isolated from a deep water specimen of a sponge of the genus Aplysina. Its structure was determined through spectroscopic methods. The compound weakly inhibited binding to the thrombin receptor with an IC50 value of 20 microM.

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Year:  1995        PMID: 7673943     DOI: 10.1021/np50120a023

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  2 in total

Review 1.  The marine bromotyrosine derivatives.

Authors:  Jiangnan Peng; Jing Li; Mark T Hamann
Journal:  Alkaloids Chem Biol       Date:  2005

2.  The natural production of organobromine compounds.

Authors:  G W Gribble
Journal:  Environ Sci Pollut Res Int       Date:  2000-03       Impact factor: 4.223

  2 in total

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