OBJECTIVE: To report an unexpected case of severe ovarian hyperstimulation syndrome (OHSS) and to compare E2 levels and number of follicles to other oocyte donors. SETTING: Private assisted reproduction technology center. PATIENTS: Healthy oocyte donors with normal menstrual cyclicity. INTERVENTIONS: Prophylactic and therapeutic use of human serum albumin infusions. MAIN OUTCOME MEASURE: The clinical development of signs and symptoms of severe OHSS. RESULTS: More than 60% of other oocyte donors had higher E2 levels and 12% had higher number of follicles without associated OHSS. CONCLUSION: The risk of developing severe OHSS cannot be predicted accurately to be low even in the absence of "risk factors."
OBJECTIVE: To report an unexpected case of severe ovarian hyperstimulation syndrome (OHSS) and to compare E2 levels and number of follicles to other oocyte donors. SETTING: Private assisted reproduction technology center. PATIENTS: Healthy oocyte donors with normal menstrual cyclicity. INTERVENTIONS: Prophylactic and therapeutic use of human serum albumin infusions. MAIN OUTCOME MEASURE: The clinical development of signs and symptoms of severe OHSS. RESULTS: More than 60% of other oocyte donors had higher E2 levels and 12% had higher number of follicles without associated OHSS. CONCLUSION: The risk of developing severe OHSS cannot be predicted accurately to be low even in the absence of "risk factors."