Literature DB >> 7671322

Suppressive effect of a neutrophil elastase inhibitor on the development of collagen-induced arthritis.

K Kakimoto1, A Matsukawa, M Yoshinaga, H Nakamura.   

Abstract

A novel neutrophil elastase inhibitor, ONO-5046, was administered to BB/DR rats and DBA/1 mice immunized with type II collagen to study its effect on the development of collagen-induced arthritis (CA), an experimental model of human rheumatoid arthritis. ONO-5046 reduced the incidence as well as the severity of CA in both rats and mice. This suppressive effect on severity was correlated with improvement of the histological findings, particularly with reduced destruction of the articular cartilage. These results indicate that neutrophil elastase may play an important role in the pathogenesis of CA.

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Year:  1995        PMID： 7671322     DOI： 10.1006/cimm.1995.1183

Source DB:  PubMed          Journal:  Cell Immunol        ISSN： 0008-8749            Impact factor:   4.868


  19 in total

Review 1.  The danger from within: alarmins in arthritis.

Authors:  Meriam Nefla; Dirk Holzinger; Francis Berenbaum; Claire Jacques
Journal:  Nat Rev Rheumatol       Date:  2016-10-13       Impact factor: 20.543

2.  Rheumatoid arthritis and genetic markers in Syrian and French populations: different effect of the shared epitope.

Authors:  Leyla Kazkaz; Hubert Marotte; Mayassa Hamwi; Marie Angélique Cazalis; Pascal Roy; Bruno Mougin; Pierre Miossec
Journal:  Ann Rheum Dis       Date:  2006-10-26       Impact factor: 19.103

3.  Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase-activated receptor-2.

Authors:  Milind M Muley; Allison R Reid; Bálint Botz; Kata Bölcskei; Zsuzsanna Helyes; Jason J McDougall
Journal:  Br J Pharmacol       Date:  2015-07-31       Impact factor: 8.739

4.  Neutrophil elastase contributes to acute lung injury induced by bilateral nephrectomy.

Authors:  Tomoko Ishii; Kent Doi; Koji Okamoto; Mitsuru Imamura; Makoto Dohi; Kazuhiko Yamamoto; Toshiro Fujita; Eisei Noiri
Journal:  Am J Pathol       Date:  2010-08-13       Impact factor: 4.307

Review 5.  Expanding the clinical indications for α(1)-antitrypsin therapy.

Authors:  Eli C Lewis
Journal:  Mol Med       Date:  2012-09-07       Impact factor: 6.354

6.  Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation.

Authors:  Monica Guma; Lisa Ronacher; Ru Liu-Bryan; Shinji Takai; Michael Karin; Maripat Corr
Journal:  Arthritis Rheum       Date:  2009-12

7.  Ligand reduces galectin-1 sensitivity to oxidative inactivation by enhancing dimer formation.

Authors:  Sean R Stowell; Moonjae Cho; Christa L Feasley; Connie M Arthur; Xuezheng Song; Jennifer K Colucci; Sougata Karmakar; Padmaja Mehta; Marcelo Dias-Baruffi; Rodger P McEver; Richard D Cummings
Journal:  J Biol Chem       Date:  2008-12-22       Impact factor: 5.157

8.  Effects of the neutrophil elastase inhibitor EL-17 in rat adjuvant-induced arthritis.

Authors:  Lorenzo Di Cesare Mannelli; Laura Micheli; Lorenzo Cinci; Mario Maresca; Claudia Vergelli; Alessandra Pacini; Mark T Quinn; Maria Paola Giovannoni; Carla Ghelardini
Journal:  Rheumatology (Oxford)       Date:  2016-03-30       Impact factor: 7.580

Review 9.  Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: implications for therapeutics.

Authors:  David J Wilkinson; Maria Del Carmen Arques; Carmen Huesa; Andrew D Rowan
Journal:  Br J Pharmacol       Date:  2018-03-30       Impact factor: 8.739

10.  Potential role of decoy B7-H4 in the pathogenesis of rheumatoid arthritis: a mouse model informed by clinical data.

Authors:  Takeshi Azuma; Gefeng Zhu; Haiying Xu; A Cecilia Rietz; Charles G Drake; Eric L Matteson; Lieping Chen
Journal:  PLoS Med       Date:  2009-10-20       Impact factor: 11.069
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