Literature DB >> 7671237

Chromosome band 11q23 translocation breakpoints are DNA topoisomerase II cleavage sites.

C A Felix1, B J Lange, M R Hosler, J Fertala, M A Bjornsti.   

Abstract

Human leukemias with 11q23 translocations occur sporadically and after cancer treatment with DNA topoisomerase II-targeted drugs. To investigate this process, we examined DNA topoisomerase II cleavage in vitro in subclones of the normal 11q23 genomic homologue and a t(9;11) translocation breakpoint junction. Cleavage was assayed with limiting dilutions of enzyme in the presence or absence of epipodophyllotoxin and ATP. The strongest sites of cleavage coincided with the t(9;11) breakpoint site and two other translocation breakpoint sites within the normal homologue. These results support the involvement of DNA topoisomerase II in the translocation process at chromosome band 11q23.

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Year:  1995        PMID： 7671237

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  20 in total

1.  MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25).

Authors:  M Osaka; J D Rowley; N J Zeleznik-Le
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-25       Impact factor: 11.205

2.  Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia.

Authors:  J L Wiemels; R N Smith; G M Taylor; O B Eden; F E Alexander; M F Greaves
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-13       Impact factor: 11.205

3.  Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemias.

Authors:  M D Megonigal; E F Rappaport; D H Jones; C S Kim; P C Nowell; B J Lange; C A Felix
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

4.  Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors.

Authors:  M D Megonigal; N K Cheung; E F Rappaport; P C Nowell; R B Wilson; D H Jones; K Addya; D G Leonard; B H Kushner; T M Williams; B J Lange; C A Felix
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-14       Impact factor: 11.205

Review 5.  Chromosomal translocations involving the MLL gene: molecular mechanisms.

Authors:  Peter D Aplan
Journal:  DNA Repair (Amst)       Date:  2006-06-21

6.  Transposition without transposase: a spontaneous mutation in bacteria.

Authors:  C A Rappleye; J R Roth
Journal:  J Bacteriol       Date:  1997-03       Impact factor: 3.490

7.  Phytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons.

Authors:  Adam C Ketron; Neil Osheroff
Journal:  Phytochem Rev       Date:  2014-03-01       Impact factor: 5.374

8.  t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes.

Authors:  M D Megonigal; E F Rappaport; D H Jones; T M Williams; B D Lovett; K M Kelly; P H Lerou; T Moulton; M L Budarf; C A Felix
Journal:  Proc Natl Acad Sci U S A       Date:  1998-05-26       Impact factor: 11.205

9.  Therapy-related myelodysplasia and acute myeloid leukemia.

Authors:  Smita Bhatia
Journal:  Semin Oncol       Date:  2013-12       Impact factor: 4.929

10.  MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3).

Authors:  O M Sobulo; J Borrow; R Tomek; S Reshmi; A Harden; B Schlegelberger; D Housman; N A Doggett; J D Rowley; N J Zeleznik-Le
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-05       Impact factor: 11.205
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