Literature DB >> 7671230

HLA A2601-restricted CTLs recognize a peptide antigen expressed on squamous cell carcinoma.

M Nakao1, H Yamana, Y Imai, Y Toh, U Toh, A Kimura, S Yanoma, T Kakegawa, K Itoh.   

Abstract

The CD4-CD8+ CTL (KE-4 CTL) cell line against autologous tumor cells was established in a patient with esophageal cancer. This KE-4 CTL recognized a peptide antigen on esophageal and lung squamous cell carcinomas in an HLA A2601-restricted manner, as evaluated by cytotoxicity against a panel of tumor cells, transfection experiments with HLA A2601 cDNA, and reconstitution with eluted peptides. None of the normal cells tested was lysed by this CTL. These results suggest the existence of HLA A2601-restricted CTL precursors recognizing a peptide antigen on SCC in a patient with esophageal cancer.

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Year:  1995        PMID： 7671230

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  19 in total

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Journal:  J Clin Invest       Date:  1997-12-01       Impact factor: 14.808

4.  Bortezomib sensitizes human esophageal squamous cell carcinoma cells to TRAIL-mediated apoptosis via activation of both extrinsic and intrinsic apoptosis pathways.

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5.  Identification of HLA-A2-restricted CTL epitopes of a novel tumour-associated antigen, KIF20A, overexpressed in pancreatic cancer.

Authors:  K Imai; S Hirata; A Irie; S Senju; Y Ikuta; K Yokomine; M Harao; M Inoue; Y Tomita; T Tsunoda; H Nakagawa; Y Nakamura; H Baba; Y Nishimura
Journal:  Br J Cancer       Date:  2010-12-21       Impact factor: 7.640

6.  A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes.

Authors:  S Shichijo; M Nakao; Y Imai; H Takasu; M Kawamoto; F Niiya; D Yang; Y Toh; H Yamana; K Itoh
Journal:  J Exp Med       Date:  1998-02-02       Impact factor: 14.307

7.  Co-introduced functional CCR2 potentiates in vivo anti-lung cancer functionality mediated by T cells double gene-modified to express WT1-specific T-cell receptor.

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8.  Adoptively transferred human lung tumor specific cytotoxic T cells can control autologous tumor growth and shape tumor phenotype in a SCID mouse xenograft model.

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Journal:  J Transl Med       Date:  2007-06-25       Impact factor: 5.531

9.  Loss of p38δ mitogen-activated protein kinase expression promotes oesophageal squamous cell carcinoma proliferation, migration and anchorage-independent growth.

Authors:  Carol O'Callaghan; Liam J Fanning; Aileen Houston; Orla P Barry
Journal:  Int J Oncol       Date:  2013-05-29       Impact factor: 5.650

10.  p38δ MAPK phenotype: an indicator of chemotherapeutic response in oesophageal squamous cell carcinoma.

Authors:  Carol O'Callaghan; Liam J Fanning; Orla P Barry
Journal:  Anticancer Drugs       Date:  2015-01       Impact factor: 2.248
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