Literature DB >> 7670935

Interleukin-1 inhibits keratan sulfate production by rabbit chondrocytes: possible role of prostaglandin E2.

K Fukuda1, K Ohtani, H Dan, S Tanaka.   

Abstract

We investigated the importance of prostaglandin E2 (PGE2) release in interleukin-1 (IL-1)-induced inhibition of aggrecan synthesis by chondrocytes. Keratan sulfate (KS) production was measured in parallel with PGE2 release in chondrocytes. IL-1 inhibited KS production and stimulated PGE2 release. In the presence of PGE2, there was a dose-dependent decrease in baseline KS production. Indomethacin and dexamethasone partially blocked the IL-1-induced PGE2 release while KS production recovered. Our results suggest that IL-1 inhibits KS production, in part, by stimulating the release of PGE2.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7670935     DOI： 10.1007/bf01782816

Source DB:  PubMed          Journal:  Inflamm Res        ISSN： 1023-3830            Impact factor:   4.575


  17 in total

1.  Identification of the keratan sulfate attachment sites on bovine fibromodulin.

Authors:  A H Plaas; P J Neame; C M Nivens; L Reiss
Journal:  J Biol Chem       Date:  1990-11-25       Impact factor: 5.157

2.  Regulation of cartilage remodeling by IL-1: evidence for autocrine synthesis of IL-1 by chondrocytes.

Authors:  C A Towle; M E Trice; F Ollivierre; B J Awbrey; B V Treadwell
Journal:  J Rheumatol       Date:  1987-05       Impact factor: 4.666

3.  Interleukin-1 beta stimulates phospholipase A2 mRNA synthesis in rabbit articular chondrocytes.

Authors:  B Lyons-Giordano; G L Davis; W Galbraith; M A Pratta; E C Arner
Journal:  Biochem Biophys Res Commun       Date:  1989-10-16       Impact factor: 3.575

4.  Effect of phorbol ester on the inhibition of proteoglycan synthesis induced by interleukin 1 and antiinflammatory drugs.

Authors:  B R Hoffman; R A Kandel; T F Cruz
Journal:  J Rheumatol       Date:  1993-10       Impact factor: 4.666

5.  Histamine H2 receptor mediates keratan sulfate secretion in rabbit chondrocytes: role of cAMP.

Authors:  K Fukuda; F Matsumura; S Tanaka
Journal:  Am J Physiol       Date:  1993-12

6.  Interleukin 1 activity in the synovial fluid of patients with rheumatoid arthritis.

Authors:  A Fontana; H Hengartner; E Weber; K Fehr; P J Grob; G Cohen
Journal:  Rheumatol Int       Date:  1982       Impact factor: 2.631

7.  Modulation of interleukin-1-induced alterations in cartilage proteoglycan metabolism by activation of protein kinase C.

Authors:  E C Arner; M A Pratta
Journal:  Arthritis Rheum       Date:  1991-08

8.  Human recombinant interleukin 1-mediated suppression of glycosaminoglycan synthesis in cultured rat costal chondrocytes.

Authors:  T Ikebe; M Hirata; T Koga
Journal:  Biochem Biophys Res Commun       Date:  1986-10-15       Impact factor: 3.575

9.  Enzyme-linked immunosorbent assay for hyaluronate using cartilage proteoglycan and an antibody to keratan sulfate.

Authors:  R L Goldberg
Journal:  Anal Biochem       Date:  1988-11-01       Impact factor: 3.365

10.  Effects of various prostanoids on the in vitro metabolism of bovine articular chondrocytes.

Authors:  D Mitrovic; L Lippiello; F Gruson; F Aprile; H J Mankin
Journal:  Prostaglandins       Date:  1981-09
View more
  6 in total

1.  Celecoxib inhibits nitric oxide production in chondrocytes of ligament-damaged osteoarthritic rat joints.

Authors:  Kenta Matsuda; Shigeru Nakamura; Takashi Matsushita
Journal:  Rheumatol Int       Date:  2006-01-26       Impact factor: 2.631

2.  Tumor necrosis factor alpha-dependent proinflammatory gene induction is inhibited by cyclic tensile strain in articular chondrocytes in vitro.

Authors:  P Long; R Gassner; S Agarwal
Journal:  Arthritis Rheum       Date:  2001-10

3.  Zonal differences in nitric oxide synthesis by bovine chondrocytes exposed to interleukin-1.

Authors:  K Fukuda; F Kumano; M Takayama; M Saito; K Otani; S Tanaka
Journal:  Inflamm Res       Date:  1995-10       Impact factor: 4.575

4.  Cyclic tensile strain suppresses catabolic effects of interleukin-1beta in fibrochondrocytes from the temporomandibular joint.

Authors:  S Agarwal; P Long; R Gassner; N P Piesco; M J Buckley
Journal:  Arthritis Rheum       Date:  2001-03

5.  Repetitive mechanical stretching modulates IL-1beta induced COX-2, MMP-1 expression, and PGE2 production in human patellar tendon fibroblasts.

Authors:  Guoguang Yang; Hee-Jeong Im; James H-C Wang
Journal:  Gene       Date:  2005-10-13       Impact factor: 3.688

6.  Cyclic tensile strain acts as an antagonist of IL-1 beta actions in chondrocytes.

Authors:  Z Xu; M J Buckley; C H Evans; S Agarwal
Journal:  J Immunol       Date:  2000-07-01       Impact factor: 5.422
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.