Literature DB >> 7670724

Reduction of vasoconstriction mediated by neuropeptide Y Y2 receptors in arterioles of the guinea-pig small intestine.

T O Neild1, C J Lewis.   

Abstract

Brief applications of a high-K+ solution were used to evoke transient constrictions of arterioles from the guinea-pig small intestine. Analogues of neuropeptide Y (NPY) selective for Y2-receptors reduced the constrictions, whereas NPY or a Y1-selective analogue potentiated the constrictions. We conclude that arteriolar smooth muscle has both Y1 and Y2 receptors, and suggest that Y2 receptors inhibit vasoconstriction by modulating the opening of voltage-sensitive Ca2+ channels. This may be related to the role of NPY that is present in some vasodilator nerves.

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Year:  1995        PMID： 7670724      PMCID： PMC1908321          DOI： 10.1111/j.1476-5381.1995.tb15865.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  10 in total

Review 1.  Neuropeptide Y receptor subtypes, Y1 and Y2.

Authors:  C Wahlestedt; L Grundemar; R Håkanson; M Heilig; G H Shen; Z Zukowska-Grojec; D J Reis
Journal:  Ann N Y Acad Sci       Date:  1990       Impact factor: 5.691

2.  A study of the phasic response of arterioles of the guinea pig small intestine to prolonged exposure to norepinephrine.

Authors:  T O Neild; N Kotecha
Journal:  Microvasc Res       Date:  1989-09       Impact factor: 3.514

3.  Effects of neuropeptide Y (NPY) at the sympathetic neuroeffector junction. Can pre- and postjunctional receptors be distinguished?

Authors:  C Wahlestedt; R Håkanson
Journal:  Med Biol       Date:  1986

4.  Y1 receptors for neuropeptide Y are coupled to mobilization of intracellular calcium and inhibition of adenylate cyclase.

Authors:  L Aakerlund; U Gether; J Fuhlendorff; T W Schwartz; O Thastrup
Journal:  FEBS Lett       Date:  1990-01-15       Impact factor: 4.124

5.  Co-localization of neuropeptide Y, vasoactive intestinal polypeptide and dynorphin in non-noradrenergic axons of the guinea pig uterine artery.

Authors:  J L Morris; I L Gibbins; J B Furness; M Costa; R Murphy
Journal:  Neurosci Lett       Date:  1985-11-20       Impact factor: 3.046

6.  A novel neuropeptide Y analog, N-acetyl [Leu28,Leu31]neuropeptide Y-(24-36), with functional specificity for the presynaptic (Y2) receptor.

Authors:  E K Potter; J A Barden; M J McCloskey; L A Selbie; A Tseng; H Herzog; J Shine
Journal:  Eur J Pharmacol       Date:  1994-05-17       Impact factor: 4.432

7.  Neuropeptide Y and pancreatic polypeptide reduce calcium currents in acutely dissociated neurons from adult rat superior cervical ganglia.

Authors:  S Foucart; D Bleakman; V P Bindokas; R J Miller
Journal:  J Pharmacol Exp Ther       Date:  1993-05       Impact factor: 4.030

8.  Effects of neuropeptide Y and agonists selective for neuropeptide Y receptor sub-types on arterioles of the guinea-pig small intestine and the rat brain.

Authors:  J Xia; T O Neild; N Kotecha
Journal:  Br J Pharmacol       Date:  1992-11       Impact factor: 8.739

9.  Characterization of vascular postsynaptic NPY receptor function and regulation and differential sensitivity of Y1 and Y2 receptor function to changes in extracellular calcium availability and prior in vitro peptide exposure.

Authors:  R E Tessel; D W Miller; G A Misse; X Dong; M B Doughty
Journal:  Neuropeptides       Date:  1993-11       Impact factor: 3.286

10.  Presynaptic inhibition of cardiac vagal postganglionic nerves by neuropeptide Y.

Authors:  E Potter
Journal:  Neurosci Lett       Date:  1987-12-16       Impact factor: 3.046
  10 in total
  1 in total

1.  Conducted depolarization in arteriole networks of the guinea-pig small intestine: effect of branching of signal dissipation.

Authors:  S S Segal; T O Neild
Journal:  J Physiol       Date:  1996-10-01       Impact factor: 5.182
  1 in total

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