Literature DB >> 7670197

Isolation of myosin light chain kinase inhibitors from microorganisms: dehydroaltenusin, altenusin, atrovenetinone, and cyclooctasulfur.

S Nakanishi1, S Toki, Y Saitoh, E Tsukuda, K Kawahara, K Ando, Y Matsuda.   

Abstract

Dehydroaltenusin, cyclooctasulfur, atrovenetinone, and altenusin were isolated from the culture broths of Penicillium verruculosum IAM-13756, Streptomyces verticillus subsp. tskushiensis ATCC-21633, Penicillium sp. SPC-16375, and Penicillium sp. SPC-16524, respectively, as new myosin light chain kinase (MLCK) inhibitors. These compounds inhibited the calmodulin-dependent activity of MLCK with IC50 values of 0.69, 0.86, 3.7, and 350 microM, respectively. Among them, dehydroaltenusin was the best MLCK inhibitor in terms of potency and selectivity examined in the purified enzyme systems.

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Year:  1995        PMID： 7670197     DOI： 10.1271/bbb.59.1333

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  8 in total

1.  Altenusin, a Nonsteroidal Microbial Metabolite, Attenuates Nonalcoholic Fatty Liver Disease by Activating the Farnesoid X Receptor.

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Journal:  Mol Pharmacol       Date:  2017-07-24       Impact factor: 4.436

2.  Azole-synergistic anti-candidal activity of altenusin, a biphenyl metabolite of the endophytic fungus Alternaria alternata isolated from Terminalia chebula Retz.

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3.  Isolation of elemental sulfur as a self-growth-inhibiting substance produced by Legionella pneumophila.

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Journal:  Appl Environ Microbiol       Date:  2002-10       Impact factor: 4.792

4.  Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites.

Authors:  Sheo B Singh; Hiranthi Jayasuriya; Raymond Dewey; Jon D Polishook; Anne W Dombrowski; Deborah L Zink; Ziqiang Guan; Javier Collado; Gonzalo Platas; Fernando Pelaez; Peter J Felock; Daria J Hazuda
Journal:  J Ind Microbiol Biotechnol       Date:  2004-01-09       Impact factor: 3.346

5.  In vitro identification and characterisation of iron chelating catechol-containing natural products and derivatives.

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Review 6.  Improving glucose and lipids metabolism: drug development based on bile acid related targets.

Authors:  Hanchen Shen; Lili Ding; Mehdi Baig; Jingyan Tian; Yang Wang; Wendong Huang
Journal:  Cell Stress       Date:  2021-01-05

7.  Anti-diabetic activities of phenolic compounds of Alternaria sp., an endophyte isolated from the leaves of desert plants growing in Egypt.

Authors:  Ahmed Elbermawi; Ahmed R Ali; Yhiya Amen; Ahmed Ashour; Kadria F Ahmad; El-Sayed S Mansour; Ahmed F Halim
Journal:  RSC Adv       Date:  2022-09-01       Impact factor: 4.036

8.  Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus Alternaria sp. SCSIOS02F49.

Authors:  Yaping Chen; Ruyan Chen; Jinhuai Xu; Yongqi Tian; Jiangping Xu; Yonghong Liu
Journal:  Molecules       Date:  2018-11-01       Impact factor: 4.411
  8 in total

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