Literature DB >> 7669473

Inhibition of phagocytosis and killing of bacteria by anaesthetic agents in vitro.

W Krumholz1, J Endrass, G Hempelmann.   

Abstract

Polymorphonuclear leucocytes (PMNL) are an essential contribution to protection from bacterial infection. We have examined the effects of thiopentone, etomidate, ketamine and flunitrazepam on phagocytosis and killing of Staphylococcus aureus and Escherichia coli by PMNL in vitro with fluorescence microscopy. All anaesthetic agents significantly inhibited both phagocytosis and bactericidal activity. The additives in the commercial preparations may have contributed to the suppression.

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Year:  1995        PMID： 7669473     DOI： 10.1093/bja/75.1.66

Source DB:  PubMed          Journal:  Br J Anaesth        ISSN： 0007-0912            Impact factor:   9.166


  7 in total

Review 1.  Anesthetics, immune cells, and immune responses.

Authors:  Shin Kurosawa; Masato Kato
Journal:  J Anesth       Date:  2008-08-07       Impact factor: 2.078

2.  Effects of Propofol and Midazolam on the Inflammation of Lungs after Intravenous Endotoxin Administration in Rats.

Authors:  Mine Gursac Celik; Ayten Saracoglu; Tolga Saracoglu; Husnu Kursad; Aysenur Dostbil; Mehmet Aksoy; Ali Ahiskalioglu; Ilker Ince
Journal:  Eurasian J Med       Date:  2015-06

Review 3.  Ketamine and peripheral inflammation.

Authors:  Marc De Kock; Sebastien Loix; Patricia Lavand'homme
Journal:  CNS Neurosci Ther       Date:  2013-04-10       Impact factor: 5.243

4.  Anaesthetic impairment of immune function is mediated via GABA(A) receptors.

Authors:  Daniel W Wheeler; Andrew J Thompson; Federico Corletto; Jill Reckless; Justin C T Loke; Nicolas Lapaque; Andrew J Grant; Pietro Mastroeni; David J Grainger; Claire L Padgett; John A O'Brien; Nigel G A Miller; John Trowsdale; Sarah C R Lummis; David K Menon; John S Beech
Journal:  PLoS One       Date:  2011-02-24       Impact factor: 3.240

5.  Pleiotropic effects of 4-hydroxynonenal on oxidative burst and phagocytosis in neutrophils.

Authors:  Balu K Chacko; Stephanie B Wall; Philip A Kramer; Saranya Ravi; Tanecia Mitchell; Michelle S Johnson; Landon Wilson; Stephen Barnes; Aimee Landar; Victor M Darley-Usmar
Journal:  Redox Biol       Date:  2016-06-23       Impact factor: 11.799

6.  Propofol specifically suppresses IL-1β secretion but increases bacterial survival in Staphylococcus aureus-infected RAW264.7 cells.

Authors:  Ming-Shan Chen; Wen-Chun Lin; Hsuan-Te Yeh; Chia-Lin Hu; Shew-Meei Sheu
Journal:  Mol Cell Biochem       Date:  2018-04-17       Impact factor: 3.396

7.  Innate Immune Response against Staphylococcus aureus Preincubated with Subinhibitory Concentration of trans-Anethole.

Authors:  Paweł Kwiatkowski; Bartosz Wojciuk; Iwona Wojciechowska-Koszko; Łukasz Łopusiewicz; Bartłomiej Grygorcewicz; Agata Pruss; Monika Sienkiewicz; Karol Fijałkowski; Edward Kowalczyk; Barbara Dołęgowska
Journal:  Int J Mol Sci       Date:  2020-06-11       Impact factor: 5.923
  7 in total

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