P C Cheung1, W F Ng, A K Chan. 1. Department of Paediatrics, Caritas Medical Centre, Shamshuipo, Kowloon, Hong Kong.
Abstract
METHODOLOGY: The clinical course of a child with neonatal haemochromatosis associated with Down syndrome is described, using case notes and post-mortem examination. RESULTS: The patient died of liver failure on day 36. Post-mortem examination showed siderosis of liver, pancreas, heart, kidney and thyroid. CONCLUSIONS: Neonatal haemochromatosis is a rare paediatric disease, the aetiology of which is unknown. Evidence suggests a disorder of fetoplacental iron handling with implications for recurrence in future pregnancies.
METHODOLOGY: The clinical course of a child with neonatal haemochromatosis associated with Down syndrome is described, using case notes and post-mortem examination. RESULTS: The patient died of liver failure on day 36. Post-mortem examination showed siderosis of liver, pancreas, heart, kidney and thyroid. CONCLUSIONS:Neonatal haemochromatosis is a rare paediatric disease, the aetiology of which is unknown. Evidence suggests a disorder of fetoplacental iron handling with implications for recurrence in future pregnancies.
Authors: Erin Neil; Josef Cortez; Aparna Joshi; Erawati V Bawle; Janet Poulik; Mark Zilberman; Mohammad F El-Baba; Beena G Sood Journal: Ital J Pediatr Date: 2010-05-18 Impact factor: 2.638