| Literature DB >> 7669337 |
J Heinrich1, M Velleman, H Schuster.
Abstract
Prophages P1 and P7 exist as unit copy DNA plasmids in the bacterial cell. Maintenance of the prophage state requires the continuous expression of two repressors: (i) C1 is a protein which negatively regulates the expression of lytic genes including the C1 inactivator gene coi, and (ii) C4 is an antisense RNA which specifically inhibits the synthesis of an anti-repressor Ant. In addition, C1 repression is strengthened by lxc encoding an auxiliary repressor protein. The repressors C1, C4 and Lxc are components of a tripartite immunity system of the two phages. Here, the mode of action of these regulatory components including their antagonists Coi and Ant is described.Entities:
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Year: 1995 PMID： 7669337 DOI： 10.1111/j.1574-6976.1995.tb00193.x
Source DB: PubMed Journal: FEMS Microbiol Rev ISSN： 0168-6445 Impact factor: 16.408