Literature DB >> 7667899

New players in the 5-HT receptor field: genes and knockouts.

J J Lucas1, R Hen.   

Abstract

In recent years, cloning has revealed the existence of no less than 14 mammalian 5-HT receptors, as well as evidence that isoforms of the 5-HT4 and 5-HT7 receptors are generated by alternative splicing. In addition, molecular biology techniques have provided new tools with which to study the function of 5-HT receptors. For example, new technologies are emerging that will allow the generation of either inducible or tissue-specific knockouts (or both). In this review José Lucas and René Hen focus on the characteristics of the most recently cloned receptors and the contribution of molecular biology to the understanding of 5-HT receptor function.

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Year:  1995        PMID： 7667899     DOI： 10.1016/s0165-6147(00)89034-3

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  10 in total

1.  Comparative receptor mapping of serotoninergic 5-HT3 and 5-HT4 binding sites.

Authors:  M L López-Rodríguez; M J Morcillo; B Benhamú; M L Rosado
Journal:  J Comput Aided Mol Des       Date:  1997-11       Impact factor: 3.686

Review 2.  Radioligands for brain 5-HT2 receptor imaging in vivo: why do we need them?

Authors:  G F Busatto
Journal:  Eur J Nucl Med       Date:  1996-08

3.  Potentiation of DOI-induced forward locomotion in rats by (-)-pindolol pretreatment.

Authors:  P Kaur; S Ahlenius
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

Review 4.  The central 5-HT3 receptor in CNS disorders.

Authors:  F E Bloom; M Morales
Journal:  Neurochem Res       Date:  1998-05       Impact factor: 3.996

5.  [3H]-Mesulergine labels 5-HT7 sites in rat brain and guinea-pig ileum but not rat jejunum.

Authors:  M Hemedah; I M Coupar; F J Mitchelson
Journal:  Br J Pharmacol       Date:  1999-01       Impact factor: 8.739

6.  The effect of SB-269970, a 5-HT(7) receptor antagonist, on 5-HT release from serotonergic terminals and cell bodies.

Authors:  C Roberts; L Allen; C J Langmead; J J Hagan; D N Middlemiss; G W Price
Journal:  Br J Pharmacol       Date:  2001-04       Impact factor: 8.739

7.  Identification of the adenylyl cyclase-activating 5-hydroxytryptamine receptor subtypes expressed in the rat submandibular gland.

Authors:  D M Bourdon; J M Camden; L A Landon; F O Levy; J T Turner
Journal:  Br J Pharmacol       Date:  2000-05       Impact factor: 8.739

8.  Absence of fenfluramine-induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice.

Authors:  J J Lucas; A Yamamoto; K Scearce-Levie; F Saudou; R Hen
Journal:  J Neurosci       Date:  1998-07-15       Impact factor: 6.167

9.  Identification and characterization of seven new exon 11-associated splice variants of the rat μ opioid receptor gene, OPRM1.

Authors:  Jin Xu; Mingming Xu; Grace C Rossi; Gavril W Pasternak; Ying-Xian Pan
Journal:  Mol Pain       Date:  2011-01-21       Impact factor: 3.395

Review 10.  Voluntary activation of muscle in humans: does serotonergic neuromodulation matter?

Authors:  Justin J Kavanagh; Janet L Taylor
Journal:  J Physiol       Date:  2022-08-01       Impact factor: 6.228
  10 in total

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