| Literature DB >> 7667278 |
B Berger1, D B Wilson, E Wolf, T Tonchev, M Milla, P S Kim.
Abstract
A method is presented that predicts coiled-coil domains in protein sequences by using pairwise residue correlations obtained from a (two-stranded) coiled-coil database of 58,217 amino acid residues. A program called PAIRCOIL implements this method and is significantly better than existing methods at distinguishing coiled coils from alpha-helices that are not coiled coils. The database of pairwise residue correlations suggests structural features that stabilize or destabilize coiled coils.Mesh:
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Year: 1995 PMID: 7667278 PMCID: PMC41136 DOI: 10.1073/pnas.92.18.8259
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN: 0027-8424 Impact factor: 11.205