[Effect of sodium salicylate on the function of glucocorticoid receptors type II and III].

The non-steroidal antiinflammatory drug sodium salicylate was studied for effects on the function of Types II and III glycocorticoid receptors of hepatic cytosol in female Wistar rats weighing 180-200 g. Scatchard and other analyses established sodium salicylate (12.5-50.0 mM)-induced reductions in the density of Type II glucocorticoid receptors and the association constant of the 3H-acetonide triamcinolone (Type II)-glucocorticoid receptor complex. The function of Type II glucocorticoid receptors was found to be inhibited by sodium salicylate in an non-concurrent way. Sodium salicylate (0.62-10.0 mM) enhanced the density of Type III glucocorticoid receptors. Depending on the dosage, sodium salicylate repeatedly increased the corticosterone-binding function of Type III glucocorticoid receptors. With this, the association constant of the complex of 3H-corticosterone and Type III glucocorticoid receptor substantially unchanged. The sodium salicylate stimulation of the function of Type III glucocorticoid receptors did not occur concurrently. The findings suggest that the non-steroidal antiinflammatory drug sodium salicylate has a great influence on the most important regulatory system of homeostasis--the glucocorticoid function which is a determinant in the pathogenesis of an inflammatory process.