Literature DB >> 7665527

Genetic analysis suggests functional interactions between the N- and C-terminal domains of the TetA(C) efflux pump encoded by pBR322.

P McNicholas1, M McGlynn, G G Guay, D M Rothstein.   

Abstract

Genetic analysis of the tetA(C) gene of pBR322 indicates the importance of two-cytoplasmic loops in the TetA(C) protein (P. McNicholas, I. Chopra, and D. M. Rothstein, J. Bacteriol. 174:7926-7933, 1992). In this study, we characterized second-site suppressor mutations that suggest a functional interaction between these two cytoplasmic regions of the protein.

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Year:  1995        PMID： 7665527      PMCID： PMC177333          DOI： 10.1128/jb.177.18.5355-5357.1995

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  27 in total

1.  Orientation of the carboxyl terminus of the transposon Tn10-encoded tetracycline resistance protein in Escherichia coli.

Authors:  A Yamaguchi; K Adachi; T Sawai
Journal:  FEBS Lett       Date:  1990-06-04       Impact factor: 4.124

2.  Topology of the transposon Tn10-encoded tetracycline resistance protein within the inner membrane of Escherichia coli.

Authors:  B Eckert; C F Beck
Journal:  J Biol Chem       Date:  1989-07-15       Impact factor: 5.157

3.  Sequence of a class E tetracycline resistance gene from Escherichia coli and comparison of related tetracycline efflux proteins.

Authors:  J D Allard; K P Bertrand
Journal:  J Bacteriol       Date:  1993-07       Impact factor: 3.490

4.  Heterogeneity of tetracycline resistance determinants.

Authors:  B Mendez; C Tachibana; S B Levy
Journal:  Plasmid       Date:  1980-03       Impact factor: 3.466

5.  Tet protein domains interact productively to mediate tetracycline resistance when present on separate polypeptides.

Authors:  R A Rubin; S B Levy
Journal:  J Bacteriol       Date:  1991-07       Impact factor: 3.490

6.  Transport of divalent cations with tetracycline as mediated by the transposon Tn10-encoded tetracycline resistance protein.

Authors:  A Yamaguchi; T Udagawa; T Sawai
Journal:  J Biol Chem       Date:  1990-03-25       Impact factor: 5.157

7.  Metal-tetracycline/H+ antiporter of Escherichia coli encoded by a transposon, Tn10. The role of the conserved dipeptide, Ser65-Asp66, in tetracycline transport.

Authors:  A Yamaguchi; N Ono; T Akasaka; T Noumi; T Sawai
Journal:  J Biol Chem       Date:  1990-09-15       Impact factor: 5.157

8.  Interdomain hybrid Tet proteins confer tetracycline resistance only when they are derived from closely related members of the tet gene family.

Authors:  R A Rubin; S B Levy
Journal:  J Bacteriol       Date:  1990-05       Impact factor: 3.490

9.  Metal-tetracycline/H+ antiporter of Escherichia coli encoded by a transposon Tn10. Histidine 257 plays an essential role in H+ translocation.

Authors:  A Yamaguchi; K Adachi; T Akasaka; N Ono; T Sawai
Journal:  J Biol Chem       Date:  1991-04-05       Impact factor: 5.157

10.  Evidence that TET protein functions as a multimer in the inner membrane of Escherichia coli.

Authors:  R K Hickman; S B Levy
Journal:  J Bacteriol       Date:  1988-04       Impact factor: 3.490
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  3 in total

1.  Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance.

Authors:  I Chopra; M Roberts
Journal:  Microbiol Mol Biol Rev       Date:  2001-06       Impact factor: 11.056

2.  Structural comparison of bacterial multidrug efflux pumps of the major facilitator superfamily.

Authors:  Indrika Ranaweera; Ugina Shrestha; K C Ranjana; Prathusha Kakarla; T Mark Willmon; Alberto J Hernandez; Mun Mun Mukherjee; Sharla R Barr; Manuel F Varela
Journal:  Trends Cell Mol Biol       Date:  2015

3.  Potential of Tetracycline Resistance Proteins To Evolve Tigecycline Resistance.

Authors:  Marius Linkevicius; Linus Sandegren; Dan I Andersson
Journal:  Antimicrob Agents Chemother       Date:  2015-11-23       Impact factor: 5.191
  3 in total

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