Literature DB >> 7664347

Lipid microspheres for drug delivery from the pharmaceutical viewpoint.

T Yamaguchi1, Y Mizushima.   

Abstract

Lipid microsphere (LM) preparations of corticosteroid, nonsteroid, anti-inflammatory drugs and prostaglandins all showed more potent activity than free drugs. The LM, with a diameter of 0.2 microns, were drug carriers prepared from soybean oil and lecithin, with the drug being incorporated within the LM. This study suggests that the LM is a very promising carrier in a drug delivery system. Future trends in this field are outlined, followed by a discussion of physicochemical properties in the evaluation of novel emulsion delivery systems.

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Year:  1994        PMID: 7664347

Source DB:  PubMed          Journal:  Crit Rev Ther Drug Carrier Syst        ISSN: 0743-4863            Impact factor:   4.889


  3 in total

1.  Fat emulsions based on structured lipids (1,3-specific triglycerides): an investigation of the in vivo fate.

Authors:  H Hedeman; H Brøndsted; A Müllertz; S Frokjaer
Journal:  Pharm Res       Date:  1996-05       Impact factor: 4.200

2.  Prolonging the in vivo residence time of prostaglandin E(1) with biodegradable nanoparticles.

Authors:  Tsutomu Ishihara; Miyuki Takahashi; Megumu Higaki; Mitsuko Takenaga; Tohru Mizushima; Yutaka Mizushima
Journal:  Pharm Res       Date:  2008-02-22       Impact factor: 4.200

3.  Biodistribution characteristics of galactosylated emulsions and incorporated probucol for hepatocyte-selective targeting of lipophilic drugs in mice.

Authors:  Emi Ishida; Chittima Managit; Shigeru Kawakami; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida
Journal:  Pharm Res       Date:  2004-06       Impact factor: 4.200

  3 in total

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