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Literature DB >> 7664265

Genetic variability of the human SRD5A2 gene: implications for prostate cancer risk.

J K Reichardt¹, N Makridakis, B E Henderson, M C Yu, M C Pike, R K Ross.

Abstract

Elevated dihydrotestosterone levels have been suggested to increase the risk of prostate cancer. The human SRD5A2 gene encodes the type II steroid 5 alpha-reductase, which converts testosterone to the more bioactive compound dihydrotestosterone. We have determined the distribution of a dinucleotide repeat in low-risk Asian-Americans, high-risk African-Americans, and intermediate-risk non-Hispanic Whites. We found this marker to be more polymorphic than previously reported, with some alleles being specific to African-Americans. Genetic variants of the SRD5A2 gene may play a role in predisposition to prostate cancer and in explaining the substantial racial/ethnic variability in risk.

Entities: Chemical Disease Gene Species

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Year: 1995 PMID： 7664265

Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701

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Cited

31 in total

1. Detection of disease genes by use of family data. II. Application to nuclear families.

Authors: I P Tu; R R Balise; A S Whittemore
Journal: Am J Hum Genet Date: 2000-03-29 Impact factor: 11.025

2. A genome screen of multiplex sibships with prostate cancer.

Authors: B K Suarez; J Lin; J K Burmester; K W Broman; J L Weber; T K Banerjee; K A Goddard; J S Witte; R C Elston; W J Catalona
Journal: Am J Hum Genet Date: 2000-03 Impact factor: 11.025

Review 3. Racial differences in the androgen/androgen receptor pathway in prostate cancer.

Authors: C A Pettaway
Journal: J Natl Med Assoc Date: 1999-12 Impact factor: 1.798

4. Identification of a novel germline missense mutation of the androgen receptor in African American men with familial prostate cancer.

Authors: Si-Yi Hu; Tao Liu; Zhen-Zhen Liu; Elisa Ledet; Cruz Velasco-Gonzalez; Diptasri M Mandal; Shahriar Koochekpour
Journal: Asian J Androl Date: 2010-02-22 Impact factor: 3.285

5. A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history.

Authors: R A Kittles; A B Baffoe-Bonnie; T Y Moses; C M Robbins; C Ahaghotu; P Huusko; C Pettaway; S Vijayakumar; J Bennett; G Hoke; T Mason; S Weinrich; J M Trent; F S Collins; S Mousses; J Bailey-Wilson; P Furbert-Harris; G Dunston; I J Powell; J D Carpten
Journal: J Med Genet Date: 2005-09-09 Impact factor: 6.318

10. Genetic polymorphisms in CYP17, CYP3A4, CYP19A1, SRD5A2, IGF-1, and IGFBP-3 and prostate cancer risk in African-American men: the Flint Men's Health Study.

Authors: Aruna V Sarma; Rodney L Dunn; Leslie A Lange; Anna Ray; Yunfei Wang; Ethan M Lange; Kathleen A Cooney
Journal: Prostate Date: 2008-02-15 Impact factor: 4.104

Genetic variability of the human SRD5A2 gene: implications for prostate cancer risk.

1. Detection of disease genes by use of family data. II. Application to nuclear families.

2. A genome screen of multiplex sibships with prostate cancer.

Review 3. Racial differences in the androgen/androgen receptor pathway in prostate cancer.

4. Identification of a novel germline missense mutation of the androgen receptor in African American men with familial prostate cancer.

5. A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history.

Review 6. Molecular mechanisms involving prostate cancer racial disparity.

Review 7. Is race an independent prognostic factor for survival from prostate cancer?

8. Molecular mechanisms involving prostate cancer racial disparity.

9. SRD5A2 and HSD3B2 polymorphisms are associated with prostate cancer risk and aggressiveness.

10. Genetic polymorphisms in CYP17, CYP3A4, CYP19A1, SRD5A2, IGF-1, and IGFBP-3 and prostate cancer risk in African-American men: the Flint Men's Health Study.