BACKGROUND: This exploratory study seeks to generate new hypotheses about the relationship between obstetric complications and schizophrenia. METHOD: The British Perinatal Mortality Survey represents 98% of all births during one week in March 1958 in Great Britain. Present State Examination (PSE), Catego diagnoses of narrowly defined schizophrenia (n = 49), broadly defined schizophrenia (n = 79), affective psychosis (n = 44) and neurosis (n = 93) were derived from case notes for all cohort members. The remainder of the cohort, surviving the perinatal period, acted as controls (n = 16 812). Variables in the British Perinatal Mortality Survey were grouped into five categories: the physique/lifestyle of the mother (including demographic characteristics), her obstetric history, the current pregnancy, the delivery and the condition of the baby. RESULTS: There were 7/17 significant differences in maternal physique/lifestyle and obstetric history between the births of schizophrenics and controls, compared to 4/40 comparisons of somatic variables relating to pregnancy, birth and the condition of the baby. This compares with 4/17 and 7/40 for affective psychotics and a total of 4/57 differences for all categories of variables when neurotics were contrasted with controls. CONCLUSIONS: The purported increased risk of obstetric complications in schizophrenics may result from the physique/lifestyle of their mothers.
BACKGROUND: This exploratory study seeks to generate new hypotheses about the relationship between obstetric complications and schizophrenia. METHOD: The British Perinatal Mortality Survey represents 98% of all births during one week in March 1958 in Great Britain. Present State Examination (PSE), Catego diagnoses of narrowly defined schizophrenia (n = 49), broadly defined schizophrenia (n = 79), affective psychosis (n = 44) and neurosis (n = 93) were derived from case notes for all cohort members. The remainder of the cohort, surviving the perinatal period, acted as controls (n = 16 812). Variables in the British Perinatal Mortality Survey were grouped into five categories: the physique/lifestyle of the mother (including demographic characteristics), her obstetric history, the current pregnancy, the delivery and the condition of the baby. RESULTS: There were 7/17 significant differences in maternal physique/lifestyle and obstetric history between the births of schizophrenics and controls, compared to 4/40 comparisons of somatic variables relating to pregnancy, birth and the condition of the baby. This compares with 4/17 and 7/40 for affective psychotics and a total of 4/57 differences for all categories of variables when neurotics were contrasted with controls. CONCLUSIONS: The purported increased risk of obstetric complications in schizophrenics may result from the physique/lifestyle of their mothers.
Authors: Roshan Chudal; Andre Sourander; Heljä-Marja Surcel; Dan Sucksdorff; Susanna Hinkka-Yli-Salomäki; Alan S Brown Journal: J Affect Disord Date: 2016-10-11 Impact factor: 4.839
Authors: J M Goldstein; S Cherkerzian; S L Buka; G Fitzmaurice; M Hornig; M Gillman; S O'Toole; R P Sloan Journal: J Dev Orig Health Dis Date: 2011-12 Impact factor: 2.401
Authors: Jaana M Suvisaari; Virpi Taxell-Lassas; Maiju Pankakoski; Jari K Haukka; Jouko K Lönnqvist; Laura T Häkkinen Journal: Schizophr Bull Date: 2012-09-20 Impact factor: 9.306
Authors: Daniel A Geller; Natalie Wieland; Kathleen Carey; Fé Vivas; Carter R Petty; Jessica Johnson; Elizabeth Reichert; David Pauls; Joseph Biederman Journal: J Child Adolesc Psychopharmacol Date: 2008-08 Impact factor: 2.576