| Literature DB >> 7663300 |
E D Popova, M N Puzin, G B Kolyvanov, A A Litvin.
Abstract
The pharmacokinetics of baclofen was studied in the rat blood plasma and brain. The concentrations of the agent were found to be considerably lower in the brain than in the plasma. This is associated with the weakly pronounced lipophilicity of the agent in question and with the protective properties of the blood-brain barrier. Baclofen penetrates into the brain middle regions to a greater extent than into cerebral hemispheres.Entities:
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Year: 1995 PMID： 7663300
Source DB: PubMed Journal: Eksp Klin Farmakol ISSN： 0869-2092