OBJECTIVE: To review our experience of different therapeutic regimens in the treatment of pseudomyxoma peritonei originating in the appendix. DESIGN: Retrospective study. SETTING: University hospital, Germany. SUBJECTS: 7 Patients with histologically confirmed pseudomyxoma peritonei. INTERVENTIONS: Debulking operations. MAIN OUTCOME MEASURES: Morbidity and mortality. RESULTS: Complete removal of the tumour was possible at the initial operation only in a patient with a benign tumour. Debulking operations helped the other six patients considerably, but all but one died eventually of complications of the disease (usually bowel obstruction). Two patients developed what were thought to be pulmonary metastases, and one liver metastases, but these were not confirmed histologically. The results of chemotherapy varied; only one patient was free of tumour for about four years and in another progress of the tumour was halted for about a year. Length of follow up ranged from 2-20 years. CONCLUSIONS: Operation is the treatment of choice for pseudomyxoma peritonei, although complete resection is rarely feasible. Because of the low morbidity and slow growth of the tumour, reoperation is always indicated for symptoms of recurrence.
OBJECTIVE: To review our experience of different therapeutic regimens in the treatment of pseudomyxoma peritonei originating in the appendix. DESIGN: Retrospective study. SETTING: University hospital, Germany. SUBJECTS: 7 Patients with histologically confirmed pseudomyxoma peritonei. INTERVENTIONS: Debulking operations. MAIN OUTCOME MEASURES: Morbidity and mortality. RESULTS: Complete removal of the tumour was possible at the initial operation only in a patient with a benign tumour. Debulking operations helped the other six patients considerably, but all but one died eventually of complications of the disease (usually bowel obstruction). Two patients developed what were thought to be pulmonary metastases, and one liver metastases, but these were not confirmed histologically. The results of chemotherapy varied; only one patient was free of tumour for about four years and in another progress of the tumour was halted for about a year. Length of follow up ranged from 2-20 years. CONCLUSIONS: Operation is the treatment of choice for pseudomyxoma peritonei, although complete resection is rarely feasible. Because of the low morbidity and slow growth of the tumour, reoperation is always indicated for symptoms of recurrence.
Authors: Min Wook Joo; Yang-Guk Chung; Soo Young Hur; Ahwon Lee; Chan Kwon Jung; Won-Hee Jee; Jong Ho Kim Journal: World J Surg Oncol Date: 2015-07-19 Impact factor: 2.754