| Literature DB >> 7660365 |
O Castañeda1, V Sotolongo, A M Amor, R Stöcklin, A J Anderson, A L Harvey, A Engström, C Wernstedt, E Karlsson.
Abstract
A peptide toxin, ShK, that blocks voltage-dependent potassium channels was isolated from the whole body extract of the Caribbean sea anemone Stichodactyla helianthus. It competes with dendrotoxin I and alpha-dendrotoxin for binding to synaptosomal membranes of rat brain, facilities acetylcholine release at an avian neuromuscular junction and suppresses K+ currents in rat dorsal root ganglion neurones in culture. Its amino acid sequence is R1SCIDTIPKS10RCTAFQCKHS20MKYRLSFCRK30TCGTC35. There is no homology with other K+ channel-blocking peptides, except for BgK from the sea anemone Bunodosoma granulifera. ShK and BgK appear to be in a different structural class from other toxins affecting K+ channels.Entities:
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Year: 1995 PMID： 7660365 DOI： 10.1016/0041-0101(95)00013-c
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033