Literature DB >> 7660364

Abbé Felice Fontana (1730-1805): founder of modern toxinology.

B J Hawgood.   

Abstract

One of the great experimentalists in toxinology, Felice Fontana, worked in Tuscany on the venom of the European viper; his classic text Traité sur le Vénin de la Vipère was published in 1781. Fontana identified fundamental questions which he proceeded to test experimentally using as quantitative an approach as possible within the technical confines of the mid to late eighteenth century. Amongst his findings are the discoveries that the constituents of viper venom can be precipitated by alcohol, that the action of the venom is myotoxic and that it produces not only coagulation of blood, but paradoxically, fluidity as well. After more than 200 years, it is time to honour his name and recall his work once more.

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Year:  1995        PMID: 7660364     DOI: 10.1016/0041-0101(95)00006-8

Source DB:  PubMed          Journal:  Toxicon        ISSN: 0041-0101            Impact factor:   3.033


  5 in total

Review 1.  Paths to the discovery of antivenom serotherapy in France.

Authors:  Rosany Bochner
Journal:  J Venom Anim Toxins Incl Trop Dis       Date:  2016-06-08

Review 2.  Snake Venoms in Drug Discovery: Valuable Therapeutic Tools for Life Saving.

Authors:  Tarek Mohamed Abd El-Aziz; Antonio Garcia Soares; James D Stockand
Journal:  Toxins (Basel)       Date:  2019-09-25       Impact factor: 4.546

3.  Integrated "omics" profiling indicates that miRNAs are modulators of the ontogenetic venom composition shift in the Central American rattlesnake, Crotalus simus simus.

Authors:  Jordi Durban; Alicia Pérez; Libia Sanz; Aarón Gómez; Fabián Bonilla; Santos Rodríguez; Danilo Chacón; Mahmood Sasa; Yamileth Angulo; José M Gutiérrez; Juan J Calvete
Journal:  BMC Genomics       Date:  2013-04-10       Impact factor: 3.969

4.  Bothrops jararaca venom metalloproteinases are essential for coagulopathy and increase plasma tissue factor levels during envenomation.

Authors:  Karine M Yamashita; André F Alves; Katia C Barbaro; Marcelo L Santoro
Journal:  PLoS Negl Trop Dis       Date:  2014-05-15

Review 5.  Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges.

Authors:  Viviane A Bastos; Francisco Gomes-Neto; Jonas Perales; Ana Gisele C Neves-Ferreira; Richard H Valente
Journal:  Toxins (Basel)       Date:  2016-08-26       Impact factor: 4.546

  5 in total

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