PURPOSE: The purpose of the present work was to study the effect of metoclopramide on urethral pressure since urethral relaxation is an important factor in vesical voiding. MATERIALS AND METHODS: Urethral pressure was measured in 6 dogs, anesthetized with propofol before and 1, 5 and 10 minutes after the administration of metoclopramide (0.5 mg/kg.) or placebo. RESULTS: A single injection of metoclopramide induced a large decrease in maximal urethral closure pressure (53 to 90%; mean 71%, p < 0.001--Anova). The decrease with placebo, 5 to 44% (mean 26%), was not significant (Anova test: p = 0.06). CONCLUSION: It is argued that a central dopaminergic action most probably accounts for this effect of metoclopramide on urethral pressure.
PURPOSE: The purpose of the present work was to study the effect of metoclopramide on urethral pressure since urethral relaxation is an important factor in vesical voiding. MATERIALS AND METHODS: Urethral pressure was measured in 6 dogs, anesthetized with propofol before and 1, 5 and 10 minutes after the administration of metoclopramide (0.5 mg/kg.) or placebo. RESULTS: A single injection of metoclopramide induced a large decrease in maximal urethral closure pressure (53 to 90%; mean 71%, p < 0.001--Anova). The decrease with placebo, 5 to 44% (mean 26%), was not significant (Anova test: p = 0.06). CONCLUSION: It is argued that a central dopaminergic action most probably accounts for this effect of metoclopramide on urethral pressure.