Literature DB >> 7658464

Expression of a novel sodium-hydrogen exchanger in the gastrointestinal tract and kidney.

F K Ghishan1, S Knobel, J A Barnard, M Breyer.   

Abstract

We have recently cloned a novel Na+/H+ exchanger (NHE-2) from rat small intestinal cDNA library. The present report characterizes the expression of (NHE-2) mRNA in the rat small intestine, stomach, and kidney using Northern blot analysis and in situ hybridization techniques. NHE-2 mRNA was detected in the surface epithelium of the stomach, villus but not crypt epithelial cells of the small intestine and in the distal convoluted, but not in the proximal tubules of the kidney. This distribution suggests a functional role in the transport of sodium across the apical membrane of the gastrointestinal tract and the kidney.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7658464     DOI： 10.1007/bf00236840

Source DB:  PubMed          Journal:  J Membr Biol        ISSN： 0022-2631            Impact factor:   1.843


  20 in total

Review 1.  Structure function of the growth factor-activatable Na+/H+ exchanger (NHE1).

Authors:  S Wakabayashi; C Sardet; P Fafournoux; L Counillon; S Meloche; G Pagés; J Pouysségur
Journal:  Rev Physiol Biochem Pharmacol       Date:  1992       Impact factor: 5.545

2.  Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins.

Authors:  J Orlowski; R A Kandasamy; G E Shull
Journal:  J Biol Chem       Date:  1992-05-05       Impact factor: 5.157

3.  Effects of graded solute diuresis on renal tubular sodium transport in the rat.

Authors:  R N Khuri; N Strieder; M Wiederholt; G Giebisch
Journal:  Am J Physiol       Date:  1975-04

4.  Primary structure and functional expression of a novel gastrointestinal isoform of the rat Na/H exchanger.

Authors:  Z Wang; J Orlowski; G E Shull
Journal:  J Biol Chem       Date:  1993-06-05       Impact factor: 5.157

Review 5.  Kinetic properties of the plasma membrane Na+-H+ exchanger.

Authors:  P S Aronson
Journal:  Annu Rev Physiol       Date:  1985       Impact factor: 19.318

6.  Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter.

Authors:  C Sardet; A Franchi; J Pouysségur
Journal:  Cell       Date:  1989-01-27       Impact factor: 41.582

7.  Sodium/proton antiport in brush-border-membrane vesicles isolated from rat small intestine and kidney.

Authors:  H Murer; U Hopfer; R Kinne
Journal:  Biochem J       Date:  1976-03-15       Impact factor: 3.857

8.  Sodium-dependent bicarbonate absorption by cortical thick ascending limb of rat kidney.

Authors:  D W Good
Journal:  Am J Physiol       Date:  1985-06

9.  Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2).

Authors:  C M Tse; S A Levine; C H Yun; M H Montrose; P J Little; J Pouyssegur; M Donowitz
Journal:  J Biol Chem       Date:  1993-06-05       Impact factor: 5.157

10.  CO2-stimulated NaCl absorption in the mouse renal cortical thick ascending limb of Henle. Evidence for synchronous Na +/H+ and Cl-/HCO3- exchange in apical plasma membranes.

Authors:  P A Friedman; T E Andreoli
Journal:  J Gen Physiol       Date:  1982-11       Impact factor: 4.086
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.