Anterior pituitary function and growth hormone use in the elderly.

Age-related changes in GH and IGF-I secretion occur in both men and women and may partially contribute to the body compositional changes of decreased lean body mass, increased adiposity, alterations in bone density, and increased cardiovascular risk, all of which can affect adversely on functional capacity. hGH, GHRH, GHRP and other trophic factors hold promise as therapeutic strategies to improve the functional status of frail elderly subjects. In addition, there is potential for hGH use in elderly patients in various catabolic states because of its anabolic effects with nitrogen retention. However, careful long-term clinical trials are necessary with development of specific targeting criteria before conclusions regarding efficacy and benefits can be decided.