J P Stevens1, T M Daniel. 1. Center for International Health, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Abstract
STUDY OBJECTIVE: To evaluate the use of ciprofloxacin and pyrazinamide for the prophylaxis of individuals infected with multiply drug-resistant strains of Mycobacterium tuberculosis. DESIGN: Decision analysis, using software (SMLTREE). Probabilities based on published studies, with sensitivity analysis for each probability. SETTING: Health-care workers infected with multidrug-resistant strains of M tuberculosis. INTERVENTIONS: Prophylaxis with ciprofloxacin and pyrazinamide. MEASUREMENTS AND RESULTS: We calculated the utilities of taking or not taking prophylaxis with ciprofloxacin and pyrazinamide. The decision analysis favored the use of ciprofloxacin-pyrazinamide prophylaxis by a small margin. CONCLUSION: Ciprofloxacin-pyrazinamide prophylaxis should be considered for health-care workers infected with multiply drug-resistant M tuberculosis.
STUDY OBJECTIVE: To evaluate the use of ciprofloxacin and pyrazinamide for the prophylaxis of individuals infected with multiply drug-resistant strains of Mycobacterium tuberculosis. DESIGN: Decision analysis, using software (SMLTREE). Probabilities based on published studies, with sensitivity analysis for each probability. SETTING: Health-care workers infected with multidrug-resistant strains of M tuberculosis. INTERVENTIONS: Prophylaxis with ciprofloxacin and pyrazinamide. MEASUREMENTS AND RESULTS: We calculated the utilities of taking or not taking prophylaxis with ciprofloxacin and pyrazinamide. The decision analysis favored the use of ciprofloxacin-pyrazinamide prophylaxis by a small margin. CONCLUSION:Ciprofloxacin-pyrazinamide prophylaxis should be considered for health-care workers infected with multiply drug-resistant M tuberculosis.
Authors: Joshua N Bress; Todd Hulgan; Jennifer A Lyon; Cecilia P Johnston; Harold Lehmann; Timothy R Sterling Journal: Am J Med Date: 2007-05 Impact factor: 4.965