Literature DB >> 7656549

Integrating parallelization strategies for linkage analysis.

S K Gupta1, A A Schäffer, A L Cox, S Dwarkadas, W Zwaenepoel.   

Abstract

We describe a second parallel implementation of the ILINK program from the LINKAGE package that improves on our previous implementation. To improve running time we integrated the strategy of parallel estimation of the gradient at a candidate recombination fraction vector with a previously implemented strategy for evaluating in parallel the likelihood at one vector. We also integrated an adaptive loadbalancing strategy in conjunction with our previous static loadbalancing strategy. We implemented a strategy for partitioning input pedigrees, but this slowed down the program; we give some evidence for what the problems are. To best exploit parallelism at all levels of the program and to take advantage of both coarse-grain and fine-grain parallelism it is necessary to combine multiple algorithmic strategies.

Mesh:

Year:  1995        PMID: 7656549     DOI: 10.1006/cbmr.1995.1009

Source DB:  PubMed          Journal:  Comput Biomed Res        ISSN: 0010-4809


  7 in total

1.  Online system for faster multipoint linkage analysis via parallel execution on thousands of personal computers.

Authors:  M Silberstein; A Tzemach; N Dovgolevsky; M Fishelson; A Schuster; D Geiger
Journal:  Am J Hum Genet       Date:  2006-05-01       Impact factor: 11.025

2.  Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27.

Authors:  H Matsumine; M Saito; S Shimoda-Matsubayashi; H Tanaka; A Ishikawa; Y Nakagawa-Hattori; M Yokochi; T Kobayashi; S Igarashi; H Takano; K Sanpei; R Koike; H Mori; T Kondo; Y Mizutani; A A Schäffer; Y Yamamura; S Nakamura; S Kuzuhara; S Tsuji; Y Mizuno
Journal:  Am J Hum Genet       Date:  1997-03       Impact factor: 11.025

3.  A novel nemaline myopathy in the Amish caused by a mutation in troponin T1.

Authors:  J J Johnston; R I Kelley; T O Crawford; D H Morton; R Agarwala; T Koch; A A Schäffer; C A Francomano; L G Biesecker
Journal:  Am J Hum Genet       Date:  2000-08-21       Impact factor: 11.025

4.  An immune defect causing dominant chronic mucocutaneous candidiasis and thyroid disease maps to chromosome 2p in a single family.

Authors:  T P Atkinson; A A Schäffer; B Grimbacher; H W Schroeder; C Woellner; C S Zerbe; J M Puck
Journal:  Am J Hum Genet       Date:  2001-08-21       Impact factor: 11.025

5.  Fine mapping of the nail-patella syndrome locus at 9q34.

Authors:  I McIntosh; M V Clough; A A Schäffer; E G Puffenberger; V K Horton; K Peters; M H Abbott; C M Roig; S Cutone; L Ozelius; D J Kwiatkowski; R E Pyeritz; L J Brown; R M Pauli; M K McCormick; C A Francomano
Journal:  Am J Hum Genet       Date:  1997-01       Impact factor: 11.025

Review 6.  Software for quantitative trait analysis.

Authors:  Laura Almasy; Diane M Warren
Journal:  Hum Genomics       Date:  2005-09       Impact factor: 4.639

7.  MLIP: using multiple processors to compute the posterior probability of linkage.

Authors:  Manika Govil; Alberto M Segre; Veronica J Vieland
Journal:  BMC Bioinformatics       Date:  2008-05-28       Impact factor: 3.169

  7 in total

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