| Literature DB >> 7656221 |
I Sugawara1, A Masunaga, S Itoyama, T Sumizawa, S Akiyama, T Yamashita.
Abstract
It was found that the mechanism of anti-cancer drug resistance in anaplastic carcinoma of the thyroid was not explicable only in terms of expression of mdr1 and its gene product, P-glycoprotein. The multidrug resistance-associated protein (MRP), another member of the mdr gene family, may be involved in anti-cancer drug resistance of this carcinoma. The MRP expression was examined immunohistochemically in 8 cell lines and 73 thyroid cancer tissues; its frequency in anaplastic carcinoma (52%) was significantly higher than that in other thyroid cancer types.Entities:
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Year: 1995 PMID： 7656221 DOI： 10.1016/0304-3835(95)03878-z
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679