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Literature DB >> 7655989

Effects of cyclosporin on serum hyaluronan levels in collagen arthritis.

K Takagishi¹, M Itoman, Y Goso, S Kuwao, H Miyahara, N Kaibara.

Abstract

Serum hyaluronan (HA) levels were measured in a rat model of collagen arthritis using a sandwich enzyme-linked immunosorbent assay. Values became elevated as the arthritis developed, correlating with its severity. Daily subcutaneous treatment with cyclosporin at the dose of 25 mg/kg per day for fourteen days completely prevented anti-type II collagen antibody production and the serum HA increase as well as development of collagen arthritis. HA in the blood may thus provide a good quantitative marker for joint disease in rat collagen arthritis with potential as a tool for evaluation of drug efficacy in this experimental model.

Entities: Chemical Disease Species

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Year: 1995 PMID： 7655989 DOI： 10.1007/bf01793217

Source DB: PubMed Journal: Inflamm Res ISSN： 1023-3830 Impact factor: 4.575

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References

24 in total

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Effects of cyclosporin on serum hyaluronan levels in collagen arthritis.

1. Circulating hyaluronate in rheumatoid arthritis: relationship to inflammatory activity and the effect of corticosteroid therapy.

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4. Assay of serum hyaluronic acid in clinical application.

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