Literature DB >> 7655444

Columbin isolated from calumbae radix affects the sleeping time of anesthetized mice.

K Wada1, T Kurihara, M Yagi, R Kobayashi, H Kaminaga, K Toi, M Haga.   

Abstract

In a screening series of bioactive components in edible and medicinal plants, we found that Calumbae Radix (Colombo root, 1% powdered feed, for 5 d) and its component, columbin (20-40 mg/kg/d, for 5 d, orally), shortened the sleeping time induced by a urethane and alpha-chloralose mixture and prolonged the sleeping time induced by hexobarbital in mice.

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Year:  1995        PMID: 7655444     DOI: 10.1248/bpb.18.634

Source DB:  PubMed          Journal:  Biol Pharm Bull        ISSN: 0918-6158            Impact factor:   2.233


  1 in total

1.  Development and validation of an UPLC-MS/MS method for the quantification of columbin in biological matrices: Applications to absorption, metabolism, and pharmacokinetic studies.

Authors:  Guangyi Yang; Song Gao; Rongjin Sun; Taijun Yin; Ming Hu
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2015-08-07       Impact factor: 3.205

  1 in total

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