Literature DB >> 7654308

HPLC determination of glycyrrhizin and glycyrrhetic acid in biological fluids, after licorice extract administration to humans and rats.

M A Raggi1, F Bugamelli, L Nobile, P Schiavone, G Cantelli-Forti.   

Abstract

Simple and sensitive HPLC methods were developed for the determination of glycyrrhyzin (G) and its main metabolite glycyrrhetic acid (GA) in biological samples, in order to investigate the pharmacokinetic behaviour of G after oral administration of licorice extract (LE) or G to humans and rats. The analysis have been carried out by HPLC with UV detector (251 nm), after a careful pretreatment of the samples. These methods are suitable in terms of precision and accuracy for the G and GA determination in plasma and urine of human volunteers and in bile, plasma ad urine of rats.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7654308

Source DB:  PubMed          Journal:  Boll Chim Farm        ISSN： 0006-6648


  3 in total

Review 1.  Pharmacokinetic evaluation of herbal remedies. Basic introduction, applicability, current status and regulatory needs.

Authors:  P A De Smet; J R Brouwers
Journal:  Clin Pharmacokinet       Date:  1997-06       Impact factor: 6.447

2.  Pharmacokinetics of Active Components of Yokukansan, a Traditional Japanese Herbal Medicine after a Single Oral Administration to Healthy Japanese Volunteers: A Cross-Over, Randomized Study.

Authors:  Hiroyuki Kitagawa; Masaya Munekage; Kengo Ichikawa; Ian Fukudome; Eri Munekage; Yuka Takezaki; Takashi Matsumoto; Yasushi Igarashi; Haruo Hanyu; Kazuhiro Hanazaki
Journal:  PLoS One       Date:  2015-07-07       Impact factor: 3.240

3.  Simultaneous HPLC analysis, with isocratic elution, of glycyrrhizin and glycyrrhetic acid in liquorice roots and confectionery products.

Authors:  Cesare Sabbioni; Anna Ferranti; Francesca Bugamelli; Giorgio Cantelli Forti; Maria Augusta Raggi
Journal:  Phytochem Anal       Date:  2006 Jan-Feb       Impact factor: 3.373
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.