Literature DB >> 7651346

Multiple domains mediate heme control of the yeast activator HAP1.

M L Haldi1, L Guarente.   

Abstract

The activity of the yeast activator HAP1 in vivo requires heme. A heme responsive domain of HAP1 was identified previously. It is adjacent to the DNA-binding domain and appears to block DNA binding in the absence of heme. Here we describe a novel genetic selection which yielded mutants of HAP1 that are independent of heme when assayed for activation. These mutants define a second region of HAP1, close to the activation domain, which also controls its response to heme.

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Year:  1995        PMID： 7651346     DOI： 10.1007/bf02190805

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  27 in total

1.  Reduced levels of hsp90 compromise steroid receptor action in vivo.

Authors:  D Picard; B Khursheed; M J Garabedian; M G Fortin; S Lindquist; K R Yamamoto
Journal:  Nature       Date:  1990-11-08       Impact factor: 49.962

2.  Organization of the regulatory region of the yeast CYC7 gene: multiple factors are involved in regulation.

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Journal:  Mol Cell Biol       Date:  1987-09       Impact factor: 4.272

Review 3.  Transcription activation by estrogen and progesterone receptors.

Authors:  H Gronemeyer
Journal:  Annu Rev Genet       Date:  1991       Impact factor: 16.830

Review 4.  Regulation of gene expression by oxygen in Saccharomyces cerevisiae.

Authors:  R S Zitomer; C V Lowry
Journal:  Microbiol Rev       Date:  1992-03

5.  The nine amino-terminal residues of delta-aminolevulinate synthase direct beta-galactosidase into the mitochondrial matrix.

Authors:  T Keng; E Alani; L Guarente
Journal:  Mol Cell Biol       Date:  1986-02       Impact factor: 4.272

6.  A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains.

Authors:  E Alani; L Cao; N Kleckner
Journal:  Genetics       Date:  1987-08       Impact factor: 4.562

7.  Antibody-promoted dimerization bypasses the regulation of DNA binding by the heme domain of the yeast transcriptional activator HAP1.

Authors:  L Zhang; O Bermingham-McDonogh; B Turcotte; L Guarente
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205

8.  Yeast HAP1 activator binds to two upstream activation sites of different sequence.

Authors:  K Pfeifer; T Prezant; L Guarente
Journal:  Cell       Date:  1987-04-10       Impact factor: 41.582

9.  A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

Authors:  R S Sikorski; P Hieter
Journal:  Genetics       Date:  1989-05       Impact factor: 4.562

10.  Heme binds to a short sequence that serves a regulatory function in diverse proteins.

Authors:  L Zhang; L Guarente
Journal:  EMBO J       Date:  1995-01-16       Impact factor: 11.598
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  7 in total

1.  The Hsp70-Ydj1 molecular chaperone represses the activity of the heme activator protein Hap1 in the absence of heme.

Authors:  T Hon; H C Lee; A Hach; J L Johnson; E A Craig; H Erdjument-Bromage; P Tempst; L Zhang
Journal:  Mol Cell Biol       Date:  2001-12       Impact factor: 4.272

2.  Molecular mechanism governing heme signaling in yeast: a higher-order complex mediates heme regulation of the transcriptional activator HAP1.

Authors:  L Zhang; A Hach; C Wang
Journal:  Mol Cell Biol       Date:  1998-07       Impact factor: 4.272

3.  The heme activator protein Hap1 represses transcription by a heme-independent mechanism in Saccharomyces cerevisiae.

Authors:  Thomas Hon; Hee Chul Lee; Zhanzhi Hu; Vishwanath R Iyer; Li Zhang
Journal:  Genetics       Date:  2005-01-16       Impact factor: 4.562

4.  A new class of repression modules is critical for heme regulation of the yeast transcriptional activator Hap1.

Authors:  A Hach; T Hon; L Zhang
Journal:  Mol Cell Biol       Date:  1999-06       Impact factor: 4.272

5.  Metabolic alterations in yeast lacking copper-zinc superoxide dismutase.

Authors:  Sadaf Sehati; Matthew H S Clement; Jake Martins; Lei Xu; Valter D Longo; Joan S Valentine; Edith B Gralla
Journal:  Free Radic Biol Med       Date:  2011-03-10       Impact factor: 7.376

6.  Regulation of the heme A biosynthetic pathway: differential regulation of heme A synthase and heme O synthase in Saccharomyces cerevisiae.

Authors:  Zhihong Wang; Yuxin Wang; Eric L Hegg
Journal:  J Biol Chem       Date:  2008-10-24       Impact factor: 5.157

7.  Structural environment dictates the biological significance of heme-responsive motifs and the role of Hsp90 in the activation of the heme activator protein Hap1.

Authors:  Hee Chul Lee; Thomas Hon; Changgui Lan; Li Zhang
Journal:  Mol Cell Biol       Date:  2003-08       Impact factor: 4.272
  7 in total

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