| Literature DB >> 7651127 |
E B Cady1, P C D'Souza, J Penrice, A Lorek.
Abstract
Brain temperature may be important for investigating pathology and cerebroprotective effects of pharmaceuticals and hypothermia. Two methods for estimating temperature using 1H magnetic resonance spectroscopy are described: a partially water-suppressed binomial sequence and non-water-suppressed point-resolved spectroscopy. Relative to N-acetylaspartate (Naa), water chemical shift (delta H2O-Naa) in piglet brain depended linearly on temperature from 30 degrees to 40 degrees C: temperature was 286.9-94.0 delta H2O-Naa degrees C. Thalamic temperature in six normal infants was 38.1 degrees +/- 0.4 degree C indicating that local brain temperature could be estimated with adequate sensitivity for studying pathologic and therapeutic changes.Entities:
Mesh:
Substances:
Year: 1995 PMID: 7651127 DOI: 10.1002/mrm.1910330620
Source DB: PubMed Journal: Magn Reson Med ISSN: 0740-3194 Impact factor: 4.668