Literature DB >> 7650482

The p47phox mouse knock-out model of chronic granulomatous disease.

S H Jackson1, J I Gallin, S M Holland.   

Abstract

Chronic granulomatous disease (CGD) is caused by a congenital defect in phagocyte reduced nicotinamide dinucleotide phosphate (NADPH) oxidase production of superoxide and related species. It is characterized by recurrent life-threatening bacterial and fungal infections and tissue granuloma formation. We have created a mouse model of CGD by targeted disruption of p47phox, one of the genes in which mutations cause human CGD. Identical to the case in human CGD, leukocytes from p47phox-/- mice produced no superoxide and killed staphylococci ineffectively. p47phox-/- mice developed lethal infections and granulomatous inflammation similar to those encountered in human CGD patients. This model mirrors human CGD and confirms a critical role for the phagocyte NADPH oxidase in mammalian host defense.

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Year:  1995        PMID： 7650482      PMCID： PMC2192153          DOI： 10.1084/jem.182.3.751

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  38 in total

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Authors:  H D Ochs; R P Igo
Journal:  J Pediatr       Date:  1973-07       Impact factor: 4.406

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Journal:  J Immunol       Date:  1981-06       Impact factor: 5.422

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Journal:  Nat Genet       Date:  1995-02       Impact factor: 38.330

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Journal:  J Exp Med       Date:  1981-11-01       Impact factor: 14.307
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  189 in total

Review 1.  Chronic granulomatous disease.

Authors:  D Goldblatt; A J Thrasher
Journal:  Clin Exp Immunol       Date:  2000-10       Impact factor: 4.330

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Journal:  Infect Immun       Date:  2003-10       Impact factor: 3.441

Review 3.  Mechanisms of resistance to oxidative and nitrosative stress: implications for fungal survival in mammalian hosts.

Authors:  Tricia A Missall; Jennifer K Lodge; Joan E McEwen
Journal:  Eukaryot Cell       Date:  2004-08

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5.  CaMKII is essential for the proasthmatic effects of oxidation.

Authors:  Philip N Sanders; Olha M Koval; Omar A Jaffer; Anand M Prasad; Thomas R Businga; Jason A Scott; Patrick J Hayden; Elizabeth D Luczak; David D Dickey; Chantal Allamargot; Alicia K Olivier; David K Meyerholz; Alfred J Robison; Danny G Winder; Timothy S Blackwell; Ryszard Dworski; David Sammut; Brett A Wagner; Garry R Buettner; Robert M Pope; Francis J Miller; Megan E Dibbern; Hans Michael Haitchi; Peter J Mohler; Peter H Howarth; Joseph Zabner; Joel N Kline; Isabella M Grumbach; Mark E Anderson
Journal:  Sci Transl Med       Date:  2013-07-24       Impact factor: 17.956

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Authors:  Qing Lu; Mark S Wainwright; Valerie A Harris; Saurabh Aggarwal; Yali Hou; Thomas Rau; David J Poulsen; Stephen M Black
Journal:  Free Radic Biol Med       Date:  2012-06-19       Impact factor: 7.376

7.  NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis.

Authors:  Ramon Bataller; Robert F Schwabe; Youkyung H Choi; Liu Yang; Yong Han Paik; Jeffrey Lindquist; Ting Qian; Robert Schoonhoven; Curt H Hagedorn; John J Lemasters; David A Brenner
Journal:  J Clin Invest       Date:  2003-11       Impact factor: 14.808

8.  Candida glabrata persistence in mice does not depend on host immunosuppression and is unaffected by fungal amino acid auxotrophy.

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Journal:  Infect Immun       Date:  2009-12-14       Impact factor: 3.441

9.  Impact of interleukin-12, oxidative burst, and iNOS on the survival of murine fecal peritonitis.

Authors:  Markus Entleutner; Tobias Traeger; Alexandra Westerholt; Bernhard Holzmann; Albrecht Stier; Klaus Pfeffer; Stefan Maier; Claus-Dieter Heidecke
Journal:  Int J Colorectal Dis       Date:  2005-03-09       Impact factor: 2.571

10.  Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4.

Authors:  Ruby F Fernandez-Boyanapalli; S Courtney Frasch; Kathleen McPhillips; R William Vandivier; Brian L Harry; David W H Riches; Peter M Henson; Donna L Bratton
Journal:  Blood       Date:  2008-10-24       Impact factor: 22.113
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