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Literature DB >> 765025

Dynamics of thymidine incorporation by spleen cells from rats infected with Plasmodium berghei.

Abstract

The in vitro incorporation of thymidine by spleen cells of rat infected with Plasmodium berghei was higher than that of normal rat spleen cells. The incorporation was proportional to the number of cells in the system and was related to the day of infection, e.g. spleen cells from malarious rats incorporated up to forty times as much thymidine as did normal spleen cells 21 days after inoculation. At the same time, the response of the malarious spleen cells to phytohaemagglutinin (PHA) was only one-twentieth of that observed for normal spleen cells. The thymidine was incorporated by non-adherent spleen cells in a single pulse during the first 8 hr in culture.

Entities: Chemical Species

Mesh：

Substances：
Lectins
Thymidine

Year: 1975 PMID： 765025 PMCID： PMC1538280

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

12 in total

1. MALARIA ANTIBODY CONTENT OF GAMMA 2-7S GLOBULIN IN TROPICAL POPULATIONS.

Authors: C C CURTAIN; C KIDSON; D L CHAMPNESS; J G GORMAN
Journal: Nature Date: 1964-09-26 Impact factor: 49.962

2. Blood loss and replacement in plasmodial infections. I. Plasmodium berghei in untreated rats of varying age and in adult rats with erythropoietic mechanisms manipulated before inoculation.

Authors: A ZUCKERMAN
Journal: J Infect Dis Date: 1957 Mar-Apr Impact factor: 5.226

3. Anaemia and erythropoiesis in the irradiated rat: an experimental study with particular reference to techniques involving radioactive iron.

Authors: C F BAXTER; E H BELCHER; E B HARRISS; L F LAMERTON
Journal: Br J Haematol Date: 1955-01 Impact factor: 6.998

4. The cellular reactions to infections with Plasmodium berghei in the white mouse.

Authors: I SINGER
Journal: J Infect Dis Date: 1954 May-Jun Impact factor: 5.226

5. Biological effects of the adjuvant Corynebacterium parvum. I. Inhibition of PHA, mixed lymphocyte and GVH reactivity.

Authors: M T Scott
Journal: Cell Immunol Date: 1972-11 Impact factor: 4.868

6. Possible role of a B-cell mitogen in hypergammaglobulinaemia in malaria and trypanosomiasis.

Authors: B M Greenwood
Journal: Lancet Date: 1974-03-16 Impact factor: 79.321

7. Immunosuppression in murine malaria. I. General characteristics.

Authors: B M Greenwood; J H Playfair; G Torrigiani
Journal: Clin Exp Immunol Date: 1971-03 Impact factor: 4.330

8. On the mode of action of BCG.

Authors: M S Mitchell; D Kirkpatrick; M B Mokyr; I Gery
Journal: Nat New Biol Date: 1973-06-13

9. Plasmodium berghei: passive transfer of immunity by antisera and cells.

Authors: R S Phillips
Journal: Exp Parasitol Date: 1970-06 Impact factor: 2.011

10. PHA-induced lymphocyte transformations in leucocyte cultures from malarious, malnourished and control Gambian children.

Authors: D L Moore; B Heyworth; J Brown
Journal: Clin Exp Immunol Date: 1974-08 Impact factor: 4.330

4 in total

4. Immune depression in trypanosome-infected mice. IV. Kinetics of suppression and alleviation by the trypanocidal drug Berenil.

Authors: G E Roelants; T W Pearson; W I Morrison; K S Mayor-Withey; L B Lundin
Journal: Clin Exp Immunol Date: 1979-09 Impact factor: 4.330