Literature DB >> 7649870

Isochromophilones III-VI, inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium multicolor FO-3216.

N Arai1, K Shiomi, H Tomoda, N Tabata, D J Yang, R Masuma, T Kawakubo, S Omura.   

Abstract

New azaphilones named isochromophilones III-VI were isolated from the culture broth of Penicillium multicolor FO-3216 as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT). Their structures were elucidated by NMR and other spectroscopic analyses. The IC50 values of isochromophilones III, IV, V and VI for ACAT activity in an enzyme assay using rat liver microsomes were calculated to be 110, 50, 50 and 120 microM, respectively.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7649870     DOI： 10.7164/antibiotics.48.696

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  9 in total

1.  Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an atlantic-forest-soil-derived Penicillium citreonigrum.

Authors:  Xiaoru Wang; José G Sena Filho; Ashley R Hoover; Jarrod B King; Trevor K Ellis; Douglas R Powell; Robert H Cichewicz
Journal:  J Nat Prod       Date:  2010-05-28       Impact factor: 4.050

2.  Discovery of secondary metabolites in an extractive liquid-surface immobilization system and its application to high-throughput interfacial screening of antibiotic-producing fungi.

Authors:  Shinobu Oda; Arisa Kameda; Masanori Okanan; Yusuke Sakakibara; Shinichi Ohashi
Journal:  J Antibiot (Tokyo)       Date:  2015-05-13       Impact factor: 2.649

3.  Classification of Aspergillus, Penicillium, Talaromyces and related genera (Eurotiales): An overview of families, genera, subgenera, sections, series and species.

Authors:  J Houbraken; S Kocsubé; C M Visagie; N Yilmaz; X-C Wang; M Meijer; B Kraak; V Hubka; K Bensch; R A Samson; J C Frisvad
Journal:  Stud Mycol       Date:  2020-06-27       Impact factor: 16.097

4.  Bioactive metabolites from Chaetomium aureum: structure elucidation and inhibition of the Hsp90 machine chaperoning activity.

Authors:  Fatima Zahra Kabbaj; Su Lu; My El Abbés Faouzi; Bouchra Meddah; Peter Proksch; Yahya Cherrah; Hans-Josef Altenbach; Amal H Aly; Ahmed Chadli; Abdessamad Debbab
Journal:  Bioorg Med Chem       Date:  2014-11-20       Impact factor: 3.641

5.  Antimicrobial Metabolites Produced by Penicillium mallochii CCH01 Isolated From the Gut of Ectropis oblique, Cultivated in the Presence of a Histone Deacetylase Inhibitor.

Authors:  Shuxiang Zhang; Han Fang; Caiping Yin; Chaoling Wei; Jingwei Hu; Yinglao Zhang
Journal:  Front Microbiol       Date:  2019-10-02       Impact factor: 5.640

6.  Anti-Inflammatory Azaphilones from the Edible Alga-Derived Fungus Penicillium sclerotiorum.

Authors:  Hui-Chun Wang; Tzu-Yi Ke; Ya-Chen Ko; Jue-Jun Lin; Jui-Sheng Chang; Yuan-Bin Cheng
Journal:  Mar Drugs       Date:  2021-09-22       Impact factor: 5.118

7.  Phytotoxic Azaphilones From the Mangrove-Derived Fungus Penicillium sclerotiorum HY5.

Authors:  Wei Wang; Mei Wang; Xian-Bo Wang; Yi-Qiang Li; Ji-Lin Ding; Ming-Xian Lan; Xi Gao; Dong-Lin Zhao; Cheng-Sheng Zhang; Guo-Xing Wu
Journal:  Front Microbiol       Date:  2022-04-19       Impact factor: 6.064

8.  Azaphilones from the Marine Sponge-Derived Fungus Penicillium sclerotiorum OUCMDZ-3839.

Authors:  Qian Jia; Yuqi Du; Chen Wang; Yi Wang; Tonghan Zhu; Weiming Zhu
Journal:  Mar Drugs       Date:  2019-04-30       Impact factor: 5.118

9.  Dereplication, Annotation, and Characterization of 74 Potential Antimicrobial Metabolites from Penicillium Sclerotiorum Using t-SNE Molecular Networks.

Authors:  Téo Hebra; Nicolas Elie; Salomé Poyer; Elsa Van Elslande; David Touboul; Véronique Eparvier
Journal:  Metabolites       Date:  2021-07-08
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.