Literature DB >> 7649245

Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase.

G C Brown1.   

Abstract

Nitric oxide (NO) reversibly inhibits mitochondrial respiration by competing with oxygen at cytochrome oxidase. Concentrations of NO measured in a range of biological systems are similar to those shown to inhibit cytochrome oxidase and mitochondrial respiration. Inhibition of NO synthesis results in a stimulation of respiration in a number of systems. It is proposed that NO exerts some of its main physiological and pathological effects on cell functions by inhibiting cytochrome oxidase. Further NO may be a physiological regulator of the affinity of mitochondrial respiration for oxygen, enabling mitochondria to act as sensors of oxygen over the physiological range.

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Year:  1995        PMID： 7649245     DOI： 10.1016/0014-5793(95)00763-y

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  110 in total

Review 1.  Endothelial nitric oxide in humans in health and disease.

Authors:  P Vallance; A Hingorani
Journal:  Int J Exp Pathol       Date:  1999-12       Impact factor: 1.925

2.  Cytochrome c-mediated formation of S-nitrosothiol in cells.

Authors:  Katarzyna A Broniowska; Agnes Keszler; Swati Basu; Daniel B Kim-Shapiro; Neil Hogg
Journal:  Biochem J       Date:  2012-02-15       Impact factor: 3.857

3.  Inhibition of nitric oxide synthase by L-NAME speeds phase II pulmonary .VO2 kinetics in the transition to moderate-intensity exercise in man.

Authors:  Andrew M Jones; Daryl P Wilkerson; Katrien Koppo; Sally Wilmshurst; Iain T Campbell
Journal:  J Physiol       Date:  2003-08-01       Impact factor: 5.182

4.  Nitric oxide protects the ultrastructure of pancreatic acinar cells in the course of caerulein-induced acute pancreatitis.

Authors:  A Andrzejewska; G Jurkowska
Journal:  Int J Exp Pathol       Date:  1999-12       Impact factor: 1.925

5.  The haemoglobin/nitric oxide cycle: involvement in flooding stress and effects on hormone signalling.

Authors:  Abir U Igamberdiev; Kevin Baron; Nathalie Manac'h-Little; Maria Stoimenova; Robert D Hill
Journal:  Ann Bot       Date:  2005-07-18       Impact factor: 4.357

Review 6.  Redox signaling.

Authors:  Henry Jay Forman; Martine Torres; Jon Fukuto
Journal:  Mol Cell Biochem       Date:  2002 May-Jun       Impact factor: 3.396

7.  Staphylococcus aureus nitric oxide synthase (saNOS) modulates aerobic respiratory metabolism and cell physiology.

Authors:  Austin B Mogen; Ronan K Carroll; Kimberly L James; Genevy Lima; Dona Silva; Jeffrey A Culver; Christopher Petucci; Lindsey N Shaw; Kelly C Rice
Journal:  Mol Microbiol       Date:  2017-05-10       Impact factor: 3.501

Review 8.  Myoglobin strikes back.

Authors:  Maurizio Brunori
Journal:  Protein Sci       Date:  2010-02       Impact factor: 6.725

9.  Functional implications of nitric oxide produced by mitochondria in mitochondrial metabolism.

Authors:  C Giulivi
Journal:  Biochem J       Date:  1998-06-15       Impact factor: 3.857

Review 10.  Reactivity of nitric oxide with cytochrome c oxidase: interactions with the binuclear centre and mechanism of inhibition.

Authors:  J Torres; C E Cooper; M Sharpe; M T Wilson
Journal:  J Bioenerg Biomembr       Date:  1998-02       Impact factor: 2.945
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