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Literature DB >> 7649202

Effect of an acidic environment on the susceptibility of Helicobacter pylori to trospectomycin and other antimicrobial agents.

Y J Debets-Ossenkopp¹, F Namavar, D M MacLaren.

Abstract

The susceptibility of 30 clinical isolates of Helicobacter pylori to trospectomycin, ampicillin, metronidazole, clarithromycin, azithromycin and clindamycin under varying pH conditions was evaluated. An acidic environment was shown to affect unfavourably the activity of all the antimicrobial agents tested. This pH effect was most marked for the two macrolides and for clindamycin.

Entities: Chemical Species

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Year: 1995 PMID： 7649202 DOI： 10.1007/bf02116532

Source DB: PubMed Journal: Eur J Clin Microbiol Infect Dis ISSN： 0934-9723 Impact factor: 3.267

15 in total

1. Stability of pH gradients in vivo across the stomach in Helicobacter pylori gastritis, dyspepsia, and health.

Authors: N J Talley; J E Ormand; C A Frie; A R Zinsmeister
Journal: Am J Gastroenterol Date: 1992-05 Impact factor: 10.864

2. Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori.

Authors: B J Marshall; C S Goodwin; J R Warren; R Murray; E D Blincow; S J Blackbourn; M Phillips; T E Waters; C R Sanderson
Journal: Lancet Date: 1988 Dec 24-31 Impact factor: 79.321

3. Failure of azythromycin to eradicate Campylobacter pylori from the stomach because of acquired resistance during treatment.

Authors: Y Glupczynski; A Burette
Journal: Am J Gastroenterol Date: 1990-01 Impact factor: 10.864

4. Azithromycin levels in plasma and gastric tissue, juice and mucus.

Authors: J D Harrison; J A Jones; D L Morris
Journal: Eur J Clin Microbiol Infect Dis Date: 1991-10 Impact factor: 3.267

5. Effect of varying pH on the susceptibility of Campylobacter pylori to antimicrobial agents.

Authors: M L Grayson; G M Eliopoulos; M J Ferraro; R C Moellering
Journal: Eur J Clin Microbiol Infect Dis Date: 1989-10 Impact factor: 3.267

6. Indicator medium for isolation of Campylobacter pylori.

Authors: D M Queiroz; E N Mendes; G A Rocha
Journal: J Clin Microbiol Date: 1987-12 Impact factor: 5.948

7. Secretion of intravenously administered antibiotics in gastric juice: implications for management of Helicobacter pylori.

Authors: S J van Zanten; J Goldie; J Hollingsworth; C Silletti; H Richardson; R H Hunt
Journal: J Clin Pathol Date: 1992-03 Impact factor: 3.411

8. In vitro susceptibility of Helicobacter pylori to trospectomycin, pirlimycin (U-57930E), mirincamycin (U-24729A) and N-demethyl clindamycin (U-26767A).

Authors: T U Westblom; B R Midkiff; S J Czinn
Journal: Eur J Clin Microbiol Infect Dis Date: 1993-07 Impact factor: 3.267

9. Cure of duodenal ulcer associated with eradication of Helicobacter pylori.

Authors: E A Rauws; G N Tytgat
Journal: Lancet Date: 1990-05-26 Impact factor: 79.321

10. Antibacterial activity of trospectomycin (U-63366F) and initial evaluations of disk diffusion susceptibility tests.

Authors: A L Barry; R N Jones; C Thornsberry
Journal: Antimicrob Agents Chemother Date: 1989-04 Impact factor: 5.191

9 in total

1. Antimicrobial susceptibilities of Helicobacter pylori isolates under microaerophilic atmospheres established by two different methods.

Authors: I Kobayashi; H Muraoka; T Saika; M Nishida; T Fujioka; M Nasu
Journal: J Clin Microbiol Date: 2001-07 Impact factor: 5.948

9. Different dose of new generation proton pump inhibitors for the treatment of Helicobacter pylori infection: A meta-analysis.

Authors: Wenwen Gao; Xiang Zhang; Yanhui Yin; Shuwen Yu; Lu Wang
Journal: Int J Immunopathol Pharmacol Date: 2021 Jan-Dec Impact factor: 3.219

9 in total

Effect of an acidic environment on the susceptibility of Helicobacter pylori to trospectomycin and other antimicrobial agents.

1. Stability of pH gradients in vivo across the stomach in Helicobacter pylori gastritis, dyspepsia, and health.

2. Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori.

3. Failure of azythromycin to eradicate Campylobacter pylori from the stomach because of acquired resistance during treatment.

4. Azithromycin levels in plasma and gastric tissue, juice and mucus.

5. Effect of varying pH on the susceptibility of Campylobacter pylori to antimicrobial agents.

6. Indicator medium for isolation of Campylobacter pylori.

7. Secretion of intravenously administered antibiotics in gastric juice: implications for management of Helicobacter pylori.

8. In vitro susceptibility of Helicobacter pylori to trospectomycin, pirlimycin (U-57930E), mirincamycin (U-24729A) and N-demethyl clindamycin (U-26767A).

9. Cure of duodenal ulcer associated with eradication of Helicobacter pylori.

10. Antibacterial activity of trospectomycin (U-63366F) and initial evaluations of disk diffusion susceptibility tests.

1. Antimicrobial susceptibilities of Helicobacter pylori isolates under microaerophilic atmospheres established by two different methods.

2. The affect of pH and bacterial phenotypic state on antibiotic efficacy.

3. In vitro and in vivo activities of tea catechins against Helicobacter pylori.

4. CYP2C19 genotype related effect of omeprazole on intragastric pH and antimicrobial stability.

5. Which is the best choice for Helicobacter pylori eradication? Dual therapy or quadruple therapy?

Review 6. Insights into the future of gastric acid suppression.

Review 7. Helicobacter pylori infection and antibiotic resistance - from biology to clinical implications.

8. Optimized high-dose amoxicillin-proton-pump inhibitor dual therapies fail to achieve high cure rates in China.

9. Different dose of new generation proton pump inhibitors for the treatment of Helicobacter pylori infection: A meta-analysis.