Literature DB >> 7648529

Pasteurella multocida toxin induces IL-6, but not IL-1 alpha or TNF alpha in fibroblasts.

S Rosendal1, P L Frandsen, J P Nielsen, R Gallily.   

Abstract

Pasteurella multocida toxin (PMT) is the major virulence factor in Progressive Atrophic Rhinitis of swine. Other workers' previous findings that PMT was mitogenic for 3T3 fibroblasts, were confirmed in the present study. In addition, PMT stimulated 3T3 cells to release IL-6, but IL-1 alpha or TNF alpha were not detected in fibroblast supernatants sampled 24, 48, or 72 h after stimulation. In view of the role of IL-6 in osteoclastic bone resorption, these findings provide a new working hypothesis for investigations into the molecular pathogenesis of this important disease.

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Year:  1995        PMID： 7648529      PMCID： PMC1263754     

Source DB:  PubMed          Journal:  Can J Vet Res        ISSN： 0830-9000            Impact factor:   1.310


  9 in total

1.  IL-6 is produced by osteoblasts and induces bone resorption.

Authors:  Y Ishimi; C Miyaura; C H Jin; T Akatsu; E Abe; Y Nakamura; A Yamaguchi; S Yoshiki; T Matsuda; T Hirano
Journal:  J Immunol       Date:  1990-11-15       Impact factor: 5.422

2.  Pasteurella multocida toxin: potent mitogen for cultured fibroblasts.

Authors:  E Rozengurt; T Higgins; N Chanter; A J Lax; J M Staddon
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

3.  Atrophic rhinitis in pigs: proposal for a revised definition.

Authors:  K B Pedersen; J P Nielsen; N T Foged; F Elling; N C Nielsen; P Willeberg
Journal:  Vet Rec       Date:  1988-02-20       Impact factor: 2.695

4.  Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

Authors:  D J Stuehr; M A Marletta
Journal:  Proc Natl Acad Sci U S A       Date:  1985-11       Impact factor: 11.205

5.  Quantitation and purification of the Pasteurella multocida toxin by using monoclonal antibodies.

Authors:  N T Foged
Journal:  Infect Immun       Date:  1988-08       Impact factor: 3.441

6.  Mycoplasma capricolum membranes induce tumor necrosis factor alpha by a mechanism different from that of lipopolysaccharide.

Authors:  T Sher; S Rottem; R Gallily
Journal:  Cancer Immunol Immunother       Date:  1990       Impact factor: 6.968

7.  Investigation into the pathogenesis of atrophic rhinitis in pigs. I. Atrophic rhinitis caused by Bordetella bronchiseptica and Pasteurella multocida and the meaning of a thermolabile toxin of P. multocida.

Authors:  M F de Jong; J P Akkermans
Journal:  Vet Q       Date:  1986-07       Impact factor: 3.320

8.  Vaccination against progressive atrophic rhinitis with a recombinant Pasteurella multocida toxin derivative.

Authors:  J P Nielsen; N T Foged; V Sørensen; K Barfod; A Bording; S K Petersen
Journal:  Can J Vet Res       Date:  1991-04       Impact factor: 1.310

9.  Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion.

Authors:  V Poli; R Balena; E Fattori; A Markatos; M Yamamoto; H Tanaka; G Ciliberto; G A Rodan; F Costantini
Journal:  EMBO J       Date:  1994-03-01       Impact factor: 11.598
  9 in total
  2 in total

Review 1.  Immunology of the porcine respiratory disease complex.

Authors:  E L Thacker
Journal:  Vet Clin North Am Food Anim Pract       Date:  2001-11       Impact factor: 3.357

2.  Receptor-interacting serine/threonine kinase 1- and 3-dependent inflammation induced in lungs of chicken infected with Pasteurella multocida.

Authors:  Weitian Li; Qiyu Tang; Na Dai; Weikuan Feng; Changqing Xie; Guofu Cheng; Xiaoli Liu; Wanpo Zhang; Xueying Hu; Changqin Gu
Journal:  Sci Rep       Date:  2020-04-14       Impact factor: 4.379
  2 in total

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